{"id":"W2135662674","doi":"10.1093/nar/gkn1069","title":"Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Biology; Genetics; Leishmania infantum; Locus (genetics); Gene; Molecular biology; Extrachromosomal DNA; Gene dosage; Genome; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006983153,0.0001889817,0.0001980423,0.0002923635,0.00007928337,0.0002039558,0.00009097339,0.0001846102,0.0006183812],"category_scores_gemma":[0.0001531224,0.0001562998,0.0001198094,0.0001984523,0.0001456276,0.00009128771,0.0001206564,0.000221695,0.0001968141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413605,"about_ca_system_score_gemma":0.00006793265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003176196,"about_ca_topic_score_gemma":0.0005957104,"domain_scores_codex":[0.9999146,0.0000109557,0.000006037109,0.00002507611,0.00002402886,0.00001913429],"domain_scores_gemma":[0.9998697,0.00002943305,0.00005727029,0.00001094029,0.00001490983,0.00001777365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002986584,0.000003279587,0.0002914031,0.000006990037,0.000001300964,0.00001793943,0.000006246015,0.000007953866,0.9993988,0.000006179125,0.000002618208,0.000227362],"study_design_scores_gemma":[0.00001503169,0.0004917383,0.1293911,0.000005783405,0.00003383013,0.0008198688,0.0001042902,0.0009555641,0.8667431,0.00006711558,0.00136437,0.000008281407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990344,0.0003175469,0.0003514334,0.00002049853,0.000001804525,0.000003260335,0.0001176215,0.00001159863,0.0001418784],"genre_scores_gemma":[0.9968604,0.000399203,0.0009770242,0.00003279868,0.000004322856,0.00001785732,0.0006126607,0.000009754461,0.001086027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006183812,"threshold_uncertainty_score":0.002068639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03907805841417195,"score_gpt":0.3260078773059972,"score_spread":0.2869298188918252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}