{"id":"W2135686776","doi":"10.1038/gt.2008.21","title":"Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trial","year":2008,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":false,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Immune system; CD8; Peripheral blood mononuclear cell; Oncolytic virus; Immunology; Cytotoxic T cell; Acquired immune system; Perforin; Granzyme B; Biology; Medicine; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008839682,0.0001397794,0.0002227122,0.00006347389,0.000156988,0.00001072185,0.0002451848,0.0001216904,0.00001522142],"category_scores_gemma":[0.00013696,0.0001114174,0.00008891597,0.0002223788,0.0001468069,0.000004561485,0.0001223508,0.000141909,0.000005188461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002542003,"about_ca_system_score_gemma":0.0002830855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001230687,"about_ca_topic_score_gemma":0.000008059545,"domain_scores_codex":[0.9983634,0.0005196912,0.0003739696,0.0003089395,0.0001847145,0.0002493226],"domain_scores_gemma":[0.9991267,0.00003109082,0.0001320206,0.0004932544,0.0001248531,0.00009202462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.3164615,0.0001608738,0.00006968086,0.000001664789,0.00006203842,0.000004256154,0.0002361093,0.000008582863,0.6758564,4.320993e-7,0.000002655672,0.007135769],"study_design_scores_gemma":[0.02155479,0.01505791,0.0153568,0.000009717534,0.000005562714,0.00002101666,0.00001280543,0.00001916682,0.9471981,0.000004829865,0.0006322522,0.0001270517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998325,0.0004565408,0.00005344189,0.0001416197,0.0001896099,0.0007970843,0.00001582542,0.000009370166,0.0000114676],"genre_scores_gemma":[0.9969409,0.002153128,0.0000790355,0.0001879316,0.0002744013,0.00002860411,0.00001267477,0.00003181513,0.00029155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2949067,"threshold_uncertainty_score":0.454347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06380306575926736,"score_gpt":0.3618060515821598,"score_spread":0.2980029858228925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}