{"id":"W2135686776","doi":"10.1038/gt.2008.21","title":"Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trial","year":2008,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":false,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Immune system; CD8; Peripheral blood mononuclear cell; Oncolytic virus; Immunology; Cytotoxic T cell; Acquired immune system; Perforin; Granzyme B; Biology; Medicine; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00122467,0.0004322681,0.0009351333,0.0002037523,0.0002211223,0.0006501377,0.0002638542,0.0005706512,0.001525115],"category_scores_gemma":[0.001091159,0.0002039478,0.0003548135,0.0002268858,0.0003851095,0.0004114023,0.0001031372,0.001158996,0.0003231594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003207585,"about_ca_system_score_gemma":0.0004492197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003326734,"about_ca_topic_score_gemma":0.0004480238,"domain_scores_codex":[0.9994472,0.0001721608,0.00002795137,0.00007528812,0.00007997734,0.0001974379],"domain_scores_gemma":[0.9994816,0.0002092131,0.00008866897,0.00006907654,0.00005191822,0.00009957158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.06933147,0.009989304,0.01050205,0.0001938414,0.0001769525,0.0004406218,0.0002859831,0.002943835,0.8280292,0.0004978008,0.001151443,0.07645746],"study_design_scores_gemma":[0.01406851,0.3994497,0.07172935,0.00004761194,0.0006355115,0.00205893,0.0003571004,0.007058345,0.4920987,0.0007377324,0.01170353,0.00005497054],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962199,0.00093884,0.001075114,0.00006804029,0.00004200252,0.0003621574,0.0002805002,0.00002443214,0.0009888556],"genre_scores_gemma":[0.9971707,0.000234912,0.0004378171,0.0001464057,0.0000287704,0.0002931384,0.0006151166,0.00001583119,0.001057189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001525115,"threshold_uncertainty_score":0.00647676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06380306575926736,"score_gpt":0.3618060515821598,"score_spread":0.2980029858228925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}