{"id":"W2135692823","doi":"10.2174/187231209787176344","title":"Molecular Analysis of the In Vivo Metabolism and Biodistribution of Metabolically and Non-Metabolically Activated Combi-Molecules of the Triazene Class","year":2009,"lang":"en","type":"article","venue":"Drug Metabolism Letters","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University","funders":"Canadian Institutes of Health Research; Innovative Research Group Project of the National Natural Science Foundation of China","keywords":"Triazene; In vivo; Chemistry; Biochemistry; Metabolism; Biodistribution; Hydrolysis; DNA; In vitro; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322563,0.0001593421,0.0001180429,0.0001246106,0.00005263712,0.0001456516,0.0001163451,0.0001915363,0.001140499],"category_scores_gemma":[0.0001388441,0.0001125215,0.000132688,0.00009404864,0.0001341654,0.0001464045,0.00003779748,0.0002814082,0.0001980116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002118217,"about_ca_system_score_gemma":0.0001140043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006415864,"about_ca_topic_score_gemma":0.0005292042,"domain_scores_codex":[0.9999611,0.000009135951,0.000001781608,0.00000867026,0.00000936326,0.000009850097],"domain_scores_gemma":[0.9999121,0.00002397462,0.0000312457,0.000009022306,0.00001270928,0.00001087388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002048921,0.00001698213,0.0001991318,0.00001372668,0.000004600779,0.00002119305,0.000007811164,0.00008061934,0.9985837,0.00006863478,0.00001194289,0.0007867587],"study_design_scores_gemma":[0.00001047258,0.0004374586,0.002398694,0.000001008256,0.00001208894,0.00009515698,0.000008591091,0.0007210386,0.9957525,0.00001434424,0.0005465152,0.000002125868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946653,0.0007521072,0.003426691,0.00003315804,0.000007092241,0.00002051042,0.0001771152,0.00002980346,0.0008882122],"genre_scores_gemma":[0.9938349,0.0006845384,0.002521337,0.00002192117,0.000004734366,0.00003809436,0.0004288531,0.00002015173,0.002445445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140499,"threshold_uncertainty_score":0.003815353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01692138713764804,"score_gpt":0.3177724496852061,"score_spread":0.3008510625475581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}