{"id":"W2135717063","doi":"10.1016/j.tibs.2009.12.007","title":"Quality control of cytoskeletal proteins and human disease","year":2010,"lang":"en","type":"review","venue":"Trends in Biochemical Sciences","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; Simon Fraser University","funders":"Canadian Institutes of Health Research","keywords":"Proteostasis; Cytoskeleton; Cell biology; Microtubule; Tubulin; Chaperonin; Biology; Intermediate filament; Actin; Protein folding; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003187374,0.000274983,0.0006709066,0.0001212639,0.00006617312,0.00002586716,0.0003962718,0.0002798468,0.00003800942],"category_scores_gemma":[0.0001750016,0.0001978402,0.0002755379,0.0002179104,0.001145592,0.000003617747,0.0001545839,0.0001971091,0.000001135318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007691936,"about_ca_system_score_gemma":0.0001279992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003892497,"about_ca_topic_score_gemma":0.00001741555,"domain_scores_codex":[0.9982453,0.0001141971,0.0004965959,0.000632502,0.0002335965,0.0002778054],"domain_scores_gemma":[0.999129,0.00003842702,0.0002516287,0.000322303,0.00002297321,0.0002356551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008036896,0.000679768,0.005124157,0.006486727,0.000081892,0.0000162834,0.00001255179,9.28816e-7,0.05137189,0.003176497,0.0004605339,0.9325084],"study_design_scores_gemma":[0.00271924,0.0007644257,0.004514592,0.004525594,0.0006437776,0.00002426532,0.00002878141,0.00001638518,0.009003621,0.000821072,0.9746557,0.00228257],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04150879,0.9567528,0.00001127691,0.00002740364,0.0000534341,0.0002304388,0.0002556992,0.000006703463,0.001153441],"genre_scores_gemma":[0.3356057,0.6636137,0.0001543254,0.00001921938,0.0001361164,0.00009831743,0.0002398985,0.0000150249,0.0001176544],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9741951,"threshold_uncertainty_score":0.8067691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03636772442999391,"score_gpt":0.3893784853679322,"score_spread":0.3530107609379383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}