{"id":"W2135763833","doi":"10.1039/c4dt02934h","title":"Iron(<scp>iii</scp>)-binding of the anticancer agents doxorubicin and vosaroxin","year":2014,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); University of British Columbia","funders":"","keywords":"Doxorubicin; Chemistry; Combinatorial chemistry; Stereochemistry; Internal medicine; Medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011794,0.000107097,0.0001347261,0.00008468465,0.00006190882,0.00008554809,0.0001662918,0.0001369894,0.001002273],"category_scores_gemma":[0.0001928206,0.00005687324,0.00006370679,0.00008658861,0.0001222849,0.00007379661,0.0001103445,0.0001674414,0.0002061389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002101723,"about_ca_system_score_gemma":0.00009801039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001183141,"about_ca_topic_score_gemma":0.001060291,"domain_scores_codex":[0.9999094,0.00002428767,0.000004742276,0.00001850512,0.00002516812,0.0000179131],"domain_scores_gemma":[0.9999365,0.00002149339,0.00001494442,0.000003699745,0.00001273462,0.00001062937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002011939,0.0000118245,0.0003518079,0.00004697034,0.000004658519,0.00002864186,0.0000131775,0.0002454802,0.9960156,0.0001068006,0.00005446301,0.002919349],"study_design_scores_gemma":[0.00001098128,0.0002933484,0.003868997,0.000003473725,0.000004937009,0.0001165596,0.00001129154,0.001785618,0.9919257,0.00003546885,0.001940396,0.000003195529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909921,0.001999686,0.00412226,0.0000487385,0.00000904617,0.00002083954,0.0001533257,0.00003550369,0.002618416],"genre_scores_gemma":[0.9972034,0.0002794499,0.001167805,0.00001608731,0.000002415409,0.000005865663,0.000173942,0.000005239856,0.001145871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001183141,"threshold_uncertainty_score":0.00335294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480308540501299,"score_gpt":0.2564008952426912,"score_spread":0.2415978098376782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}