{"id":"W2135763833","doi":"10.1039/c4dt02934h","title":"Iron(<scp>iii</scp>)-binding of the anticancer agents doxorubicin and vosaroxin","year":2014,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); University of British Columbia","funders":"","keywords":"Doxorubicin; Chemistry; Combinatorial chemistry; Stereochemistry; Internal medicine; Medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001708624,0.0001078326,0.000212848,0.00006698105,0.0001469919,0.00001090815,0.00005870526,0.00009587968,0.0000318399],"category_scores_gemma":[0.0000313797,0.00008403797,0.0001216991,0.0002049586,0.0001200491,0.0000719239,0.000003672007,0.00020458,0.000004984824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004281547,"about_ca_system_score_gemma":0.00003814512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000769219,"about_ca_topic_score_gemma":0.00003461769,"domain_scores_codex":[0.9992096,0.00004759643,0.0001893121,0.0001774404,0.0002113749,0.0001646373],"domain_scores_gemma":[0.9994603,0.000104458,0.00006915112,0.0002455988,0.00003816909,0.00008227413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001367209,0.00008210892,0.001299467,0.0001062125,0.00007509417,5.993866e-7,0.001434676,0.00005603558,0.9853961,0.0002154098,0.0002281933,0.01109237],"study_design_scores_gemma":[0.001395251,0.00007008618,0.01919436,0.0001122817,0.0001682797,0.00002935552,0.0004249271,0.0004609497,0.9706952,0.00008112128,0.007324617,0.00004358806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804572,0.00005811735,0.01487637,0.0006078103,0.0002210032,0.0003014857,0.00001996586,0.00003418797,0.003423833],"genre_scores_gemma":[0.9977556,0.0001382207,0.0002043742,0.0003971405,0.00008342892,0.00001292772,0.000007479176,0.00001713639,0.001383637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0178949,"threshold_uncertainty_score":0.3426969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480308540501299,"score_gpt":0.2564008952426912,"score_spread":0.2415978098376782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}