{"id":"W2135770992","doi":"10.1139/o11-092","title":"Histone H3 phosphorylation, immediate-early gene expression, and the nucleosomal response: a historical perspective<sup>1</sup>This article is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal’s usual peer review process.","year":2012,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Histone H3; Chromatin; MAPK/ERK pathway; Histone; Phosphorylation; Cell biology; Kinase; Biology; Regulation of gene expression; p38 mitogen-activated protein kinases; Epigenetics; Cancer research; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000448561,0.000880485,0.0008660961,0.002283677,0.0003742087,0.001312476,0.0007967972,0.00129669,0.002533739],"category_scores_gemma":[0.000604296,0.0002677615,0.0002538096,0.00346905,0.0009751586,0.002324669,0.0007207436,0.001933455,0.00213517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008912048,"about_ca_system_score_gemma":0.0009698124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008457336,"about_ca_topic_score_gemma":0.001271884,"domain_scores_codex":[0.9998603,0.00002629806,0.00001721107,0.00003574078,0.00004399391,0.0000165059],"domain_scores_gemma":[0.9996936,0.0001505742,0.00003685605,0.00001010804,0.00007345873,0.00003546945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001170164,0.00007606075,0.0002996361,0.01852885,0.00007037569,0.000362745,0.0002466548,0.0004302587,0.003081236,0.01408431,0.06114748,0.9015554],"study_design_scores_gemma":[0.000004166451,0.0000707912,0.0007482881,0.001977707,0.00003238845,0.001043092,0.0001105568,0.00004383186,0.0003636741,0.003122512,0.9924687,0.00001431342],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005876033,0.998381,0.00006558878,0.0002932276,0.0004785293,0.000001208042,0.000006676568,0.000003386106,0.000711597],"genre_scores_gemma":[0.0005306698,0.9980249,0.0001029888,0.0002718815,0.0005400684,0.000002800212,0.00001333633,0.000001392023,0.0005118815],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002533739,"threshold_uncertainty_score":0.008476198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02487819811069194,"score_gpt":0.2840567554401195,"score_spread":0.2591785573294276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}