{"id":"W2135770992","doi":"10.1139/o11-092","title":"Histone H3 phosphorylation, immediate-early gene expression, and the nucleosomal response: a historical perspective<sup>1</sup>This article is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal’s usual peer review process.","year":2012,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Histone H3; Chromatin; MAPK/ERK pathway; Histone; Phosphorylation; Cell biology; Kinase; Biology; Regulation of gene expression; p38 mitogen-activated protein kinases; Epigenetics; Cancer research; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001611655,0.000415154,0.0008862666,0.00003122258,0.0003448482,0.00003797481,0.0003007909,0.0005928925,0.0006906522],"category_scores_gemma":[0.0005338574,0.0002503688,0.0001993865,0.0001164927,0.0008717251,0.000009251256,0.000225039,0.0004373966,0.00001000106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007893047,"about_ca_system_score_gemma":0.0003083286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002181435,"about_ca_topic_score_gemma":7.08098e-7,"domain_scores_codex":[0.9975502,0.0007182107,0.0006724559,0.0004967993,0.0002244175,0.0003379151],"domain_scores_gemma":[0.998272,0.0001777253,0.0006265205,0.0004208995,0.0003228894,0.000179968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005929431,0.0009850537,0.0002202829,0.03539367,0.001436816,0.00002848963,0.009308469,4.045442e-7,0.5203785,0.0001550961,0.2440735,0.1820902],"study_design_scores_gemma":[0.00082862,0.0001950037,0.00000539496,0.0008143681,0.000559582,0.0002221736,0.0001729744,0.000001576276,0.09466939,0.00005243602,0.9021767,0.0003018198],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02285906,0.9744265,0.000009312344,0.00136579,0.000124267,0.0005360179,0.0001034492,0.000006878679,0.000568744],"genre_scores_gemma":[0.01152473,0.9813203,0.00007746569,0.0001805679,0.001944707,0.00007074269,0.00009870695,0.00003603072,0.004746748],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6581032,"threshold_uncertainty_score":0.9999949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02487819811069194,"score_gpt":0.2840567554401195,"score_spread":0.2591785573294276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}