{"id":"W2135787796","doi":"10.1186/s13073-014-0107-1","title":"Complex host genetics influence the microbiome in inflammatory bowel disease","year":2014,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":430,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Army Research Office; National Institute of Dental and Craniofacial Research; Universitair Medisch Centrum Groningen; National Human Genome Research Institute; Department of Psychiatry, University of Toronto; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute of Diabetes and Digestive and Kidney Diseases; Crohn's and Colitis Foundation of Canada; Broad Institute; Crohn's and Colitis Foundation; University of Minnesota; University of Toronto; Division of Biological Infrastructure; Massachusetts General Hospital; Crohn's and Colitis Foundation of America; National Institutes of Health; National Science Foundation","keywords":"Human genetics; Inflammatory bowel disease; Microbiome; Inflammatory Bowel Diseases; Host (biology); Computational biology; Disease; Biology; Medicine; Bioinformatics; Genetics; Evolutionary biology; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006521794,0.0004159872,0.0003004172,0.0003745558,0.000267905,0.0006267193,0.000178583,0.0004785709,0.002461838],"category_scores_gemma":[0.001640915,0.000163308,0.0002948441,0.0003903746,0.0004646679,0.000235322,0.0005096151,0.0003794853,0.000144855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002531458,"about_ca_system_score_gemma":0.0002450459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006654423,"about_ca_topic_score_gemma":0.001063155,"domain_scores_codex":[0.9995239,0.0002343481,0.00002726923,0.00009997763,0.00006075278,0.00005370389],"domain_scores_gemma":[0.9988948,0.000455755,0.0003709376,0.00008105349,0.00006137307,0.0001362271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00157768,0.0001198428,0.9411706,0.0002010072,0.0004913499,0.0008188806,0.0002994955,0.0006832376,0.04065697,0.0005604608,0.0003798846,0.01304061],"study_design_scores_gemma":[0.00004097042,0.0001658646,0.9944728,0.00003619588,0.0001884334,0.0007485073,0.0001212628,0.0007961781,0.001770841,0.0008924147,0.0007548918,0.000011463],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996479,0.001988675,0.0006511946,0.0001888836,0.00001229654,0.00001039005,0.0001520666,0.00001306301,0.0005043657],"genre_scores_gemma":[0.9984492,0.0005316805,0.0006980552,0.00006358093,0.00001128065,0.000007417178,0.00007234489,0.000007397512,0.0001588742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002461838,"threshold_uncertainty_score":0.008235693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009190186086397052,"score_gpt":0.2503192520018913,"score_spread":0.2411290659154942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}