{"id":"W2135789473","doi":"10.1128/jvi.77.5.2892-2902.2003","title":"A Single Amino Acid Substitution in Herpes Simplex Virus Type 1 VP16 Inhibits Binding to the Virion Host Shutoff Protein and Is Incompatible with Virus Growth","year":2003,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute","keywords":"Biology; Virus; Complementation; Molecular biology; Herpes simplex virus; Mutant; Amino acid; Virology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001947197,0.0006425838,0.0004168289,0.0002133206,0.0001985362,0.0003270177,0.0005789641,0.0003673295,0.001484361],"category_scores_gemma":[0.0002525823,0.0002911451,0.0003726789,0.0002261282,0.0005873818,0.0002074894,0.0003489451,0.0006675444,0.0007245436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004630761,"about_ca_system_score_gemma":0.0003840449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000334953,"about_ca_topic_score_gemma":0.0004227429,"domain_scores_codex":[0.999731,0.00007056325,0.0000449534,0.00004256143,0.00007089734,0.0000400701],"domain_scores_gemma":[0.9996085,0.00009229167,0.0001481191,0.00005962789,0.0000147625,0.00007680667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000119004,0.00004659631,0.0001597691,0.00002680687,0.000009589667,0.00006570093,0.0000089377,0.00009902244,0.9986452,0.000113351,0.00001477883,0.0006911003],"study_design_scores_gemma":[0.00004736882,0.0006720865,0.002923521,0.00001007834,0.00001860017,0.0006128107,0.00001492661,0.0007342268,0.992197,0.00007298579,0.002685892,0.00001058286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971814,0.0004624302,0.001439589,0.0000405457,0.0000309544,0.00003679433,0.0001549835,0.00005945084,0.0005938653],"genre_scores_gemma":[0.9923659,0.0003914367,0.004462202,0.00002542869,0.00001208424,0.00006124817,0.0006177363,0.00003749879,0.002026435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001484361,"threshold_uncertainty_score":0.004965723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0225050299189463,"score_gpt":0.2721420881882173,"score_spread":0.249637058269271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}