{"id":"W2135805417","doi":"10.1124/jpet.103.056705","title":"The Thromboxane Receptor Antagonist PBT-3, a Hepoxilin Stable Analog, Selectively Antagonizes the TPα Isoform in Transfected COS-7 Cells","year":2003,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Heart, Lung, and Blood Institute; National Institute for Health and Care Research","keywords":"Antagonist; Gene isoform; Transfection; Chemistry; Pharmacology; Receptor; Receptor antagonist; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000743192,0.0001915579,0.0002351567,0.00004110786,0.0003735138,0.00004948333,0.0002182859,0.0001410507,0.0001271538],"category_scores_gemma":[0.000007371548,0.000115535,0.0001083611,0.0001328425,0.0002290682,0.00001454109,0.00002630694,0.0003247898,0.000001470604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005076097,"about_ca_system_score_gemma":0.0001469629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007805416,"about_ca_topic_score_gemma":0.000011242,"domain_scores_codex":[0.9985899,0.0003575041,0.0004123851,0.0001742049,0.0001382535,0.0003277084],"domain_scores_gemma":[0.9994784,0.00008336424,0.0001949387,0.00008874976,0.0000938732,0.00006069522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006883491,0.0002105844,0.0001609583,0.000003983005,0.0002493087,0.000005662994,0.0005716603,0.00004306367,0.9967675,0.0001719622,0.0006948477,0.0004321147],"study_design_scores_gemma":[0.001709656,0.0009839028,0.00005486242,0.000006126876,0.00004939975,0.00009847717,0.001873516,0.00006299727,0.9430726,0.00009947186,0.05185262,0.000136386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983582,0.01437219,0.0003810967,0.0003769624,0.0009116243,0.0002254287,0.000008000467,0.000003543792,0.0001391319],"genre_scores_gemma":[0.9915652,0.006761303,0.0003302449,0.001012472,0.0001681349,0.00001060071,0.00000351735,0.0000202076,0.000128349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05369492,"threshold_uncertainty_score":0.4711381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241643617332608,"score_gpt":0.2890059913899419,"score_spread":0.2765895552166158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}