{"id":"W2135805417","doi":"10.1124/jpet.103.056705","title":"The Thromboxane Receptor Antagonist PBT-3, a Hepoxilin Stable Analog, Selectively Antagonizes the TPα Isoform in Transfected COS-7 Cells","year":2003,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Heart, Lung, and Blood Institute; National Institute for Health and Care Research","keywords":"Antagonist; Gene isoform; Transfection; Chemistry; Pharmacology; Receptor; Receptor antagonist; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004364476,0.0003806363,0.0006664929,0.0002904,0.000447421,0.0006862152,0.000541607,0.000441894,0.001824331],"category_scores_gemma":[0.0002356051,0.0003438183,0.0004759677,0.0003572427,0.00045281,0.0003604227,0.0001760507,0.001699268,0.001350741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005545095,"about_ca_system_score_gemma":0.0004286511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002068814,"about_ca_topic_score_gemma":0.002579465,"domain_scores_codex":[0.9995529,0.00008117507,0.00005228795,0.00006952509,0.0001426536,0.0001014],"domain_scores_gemma":[0.9998043,0.00006563457,0.00002914923,0.00003535385,0.00002577233,0.00003982313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001096048,0.00002647033,0.00004249249,0.00002125911,0.000007161191,0.00005949847,0.00002013054,0.00003131545,0.998982,0.0001816169,0.0001027745,0.0004156928],"study_design_scores_gemma":[0.00004526998,0.0001398163,0.0007948449,0.000003056404,0.00001931593,0.0003244054,0.00003610081,0.0008356407,0.9953754,0.00004313307,0.002378597,0.000004279571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816926,0.002119632,0.008231208,0.0006544787,0.0002328492,0.00006873536,0.001356649,0.0002594738,0.00538435],"genre_scores_gemma":[0.9744179,0.003013477,0.008985233,0.0003379653,0.00007657379,0.0001170234,0.003253379,0.0001524675,0.009645983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002068814,"threshold_uncertainty_score":0.006102979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241643617332608,"score_gpt":0.2890059913899419,"score_spread":0.2765895552166158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}