{"id":"W2135812015","doi":"10.1146/annurev.pharmtox.48.113006.094731","title":"Epigenetics and Complex Disease: From Etiology to New Therapeutics","year":2007,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Institute of Mental Health","keywords":"Epigenetics; Disease; Bioinformatics; Epigenesis; Medicine; Epigenetic therapy; Computational biology; Biology; Neuroscience; DNA methylation; Genetics; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006411814,0.0008446259,0.001238903,0.001470342,0.0003924239,0.001087303,0.000857365,0.001632678,0.003558923],"category_scores_gemma":[0.0005776816,0.000223015,0.0003080578,0.001425342,0.001622087,0.002051444,0.0008397019,0.001904334,0.002183508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001114925,"about_ca_system_score_gemma":0.001107097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008999132,"about_ca_topic_score_gemma":0.001947435,"domain_scores_codex":[0.9997841,0.00006196147,0.00001867666,0.00003194867,0.00008779726,0.00001550756],"domain_scores_gemma":[0.9997535,0.0001345351,0.00002083862,0.00001046193,0.00005151327,0.00002910958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005815502,0.00006605046,0.0002812307,0.005694976,0.00005918117,0.0006371255,0.0002029654,0.0005803626,0.002864406,0.0269503,0.06230165,0.9003035],"study_design_scores_gemma":[0.0000171308,0.00006712091,0.0006079138,0.00173574,0.00002874689,0.002718857,0.0001661675,0.0001506055,0.0005789317,0.01869796,0.9752095,0.00002135933],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009593814,0.9962319,0.0004405428,0.001329349,0.0004436591,0.000002823818,0.00000457092,0.000009236859,0.00144202],"genre_scores_gemma":[0.0007290788,0.9967899,0.000370791,0.0005047213,0.0005091441,0.000005191207,0.000007140491,0.000001784202,0.001082219],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003558923,"threshold_uncertainty_score":0.01190585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07071725108616163,"score_gpt":0.4270927138479714,"score_spread":0.3563754627618098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}