{"id":"W2135842910","doi":"10.1093/jac/dkq338","title":"Differential impact of the HIV-1 non-nucleoside reverse transcriptase inhibitor mutations K103N and M230L on viral replication and enzyme function","year":2010,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Etravirine; Virology; Efavirenz; Nevirapine; Reverse transcriptase; Biology; Resistance mutation; Polymerase; Virus; Viral replication; Enzyme; RNA; Genetics; Viral load; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001980306,0.0003479105,0.0003031774,0.0001338189,0.0001085443,0.0004200776,0.0002546507,0.0003470324,0.001273325],"category_scores_gemma":[0.0003794254,0.0001345638,0.0002460777,0.0001252459,0.0002072395,0.0001984344,0.0001535381,0.0003837766,0.0003187942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003963664,"about_ca_system_score_gemma":0.0002008225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001370078,"about_ca_topic_score_gemma":0.001436588,"domain_scores_codex":[0.9996917,0.00006758493,0.000033222,0.00006122063,0.00009186187,0.00005432865],"domain_scores_gemma":[0.999797,0.00006255937,0.00005551202,0.00001695149,0.00002596021,0.00004191682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002877801,0.00008688869,0.0008725838,0.00002904329,0.00001670539,0.0001245646,0.00001525622,0.0002041877,0.9964499,0.00003719464,0.00002270681,0.001853092],"study_design_scores_gemma":[0.00003446127,0.001627791,0.01220609,0.00001047796,0.00004045903,0.001068612,0.00004421257,0.001849485,0.9823352,0.00003250637,0.0007387458,0.00001209417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989134,0.0002943362,0.000280174,0.00001476661,0.000005145067,0.000008994867,0.0001182369,0.00001519384,0.000349731],"genre_scores_gemma":[0.9985918,0.0001448153,0.0006107416,0.00002182747,0.000002190599,0.00001220267,0.0002065479,0.00001321743,0.0003966072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001370078,"threshold_uncertainty_score":0.004259706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005923284717802017,"score_gpt":0.2485986455590442,"score_spread":0.2426753608412422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}