{"id":"W2135847472","doi":"10.2337/diabetes.51.4.1194","title":"Altered Phosphodiesterase 3-Mediated cAMP Hydrolysis Contributes to a Hypermotile Phenotype in Obese JCR:LA-cp Rat Aortic Vascular Smooth Muscle Cells","year":2002,"lang":"en","type":"article","venue":"Diabetes","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Queen's University","funders":"","keywords":"Phosphodiesterase 3; Vascular smooth muscle; Forskolin; Internal medicine; Endocrinology; Phosphodiesterase; Adenylyl cyclase; Biology; Medicine; Receptor; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022623,0.0006194335,0.0004305967,0.0007463977,0.0002761279,0.0003903573,0.0002525245,0.0005154673,0.00177665],"category_scores_gemma":[0.0001587323,0.0004562444,0.0004954035,0.0003488925,0.0004608231,0.0002524348,0.0003568773,0.001271848,0.0005356332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184927,"about_ca_system_score_gemma":0.000197183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009980358,"about_ca_topic_score_gemma":0.0009193124,"domain_scores_codex":[0.9997354,0.00003493725,0.00003143419,0.00005853267,0.0000776516,0.00006199439],"domain_scores_gemma":[0.9996233,0.00003446063,0.0001343935,0.00005110076,0.00002410425,0.0001326604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001141466,0.00002943064,0.0001888885,0.0000121179,0.000002995499,0.00009614808,0.00001035064,0.00000827143,0.9993512,0.00002053379,0.00001420313,0.0001517118],"study_design_scores_gemma":[0.0001058806,0.00125979,0.08546594,0.00001916897,0.00005932181,0.003436125,0.0001868697,0.001019559,0.9070498,0.0001037966,0.001267922,0.00002580761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978718,0.0003987518,0.0008963253,0.00008618515,0.00002319589,0.00001558918,0.0002696166,0.0000546162,0.0003839944],"genre_scores_gemma":[0.9955881,0.0007967278,0.001336762,0.0001027266,0.00003867051,0.00005145543,0.0005808595,0.00004243229,0.00146235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00177665,"threshold_uncertainty_score":0.005943418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006253819205300518,"score_gpt":0.1970697102102874,"score_spread":0.1908158910049868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}