{"id":"W2135907949","doi":"10.1016/s1474-4422(08)70065-6","title":"Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial","year":2008,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":587,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Neurturin; Tolerability; Medicine; Adverse effect; Adeno-associated virus; Dyskinesia; Internal medicine; Parkinson's disease; Neurotrophic factors; Clinical trial; Disease; Oncology; Glial cell line-derived neurotrophic factor; Vector (molecular biology); Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001183157,0.002185821,0.002727085,0.0004221767,0.0004254792,0.001357371,0.0009502677,0.002540399,0.003925054],"category_scores_gemma":[0.001349742,0.0007138008,0.002281647,0.0004132046,0.00161558,0.001653321,0.0002279733,0.004254607,0.0009948038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008201329,"about_ca_system_score_gemma":0.000739327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006993258,"about_ca_topic_score_gemma":0.001024453,"domain_scores_codex":[0.9994813,0.0002376577,0.00002359494,0.0001042785,0.00003810048,0.0001150869],"domain_scores_gemma":[0.9993005,0.0002183268,0.0001532002,0.00006251923,0.00003599523,0.0002295172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9271706,0.01466358,0.0008194838,0.0005729174,0.001053669,0.0001279858,0.0001525487,0.001000398,0.01424341,0.0002328831,0.0009927046,0.03896984],"study_design_scores_gemma":[0.6670769,0.3250526,0.002531763,0.00004078976,0.0006061148,0.0001243558,0.00006195376,0.001058069,0.002312743,0.0002760509,0.0008195643,0.00003911282],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918036,0.003847017,0.0007378081,0.000436988,0.0002625919,0.0006620832,0.0005781735,0.0001240504,0.001547612],"genre_scores_gemma":[0.9941465,0.001764313,0.0004464157,0.0004264207,0.0002270568,0.0006431163,0.0005806598,0.0000268293,0.001738786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003925054,"threshold_uncertainty_score":0.01313061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03740364909792256,"score_gpt":0.3094398217889936,"score_spread":0.2720361726910711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}