{"id":"W2135915392","doi":"10.1091/mbc.e02-06-0352","title":"Membrane Targeting of Grb2-associated Binder-1 (Gab1) Scaffolding Protein through Src Myristoylation Sequence Substitutes for Gab1 Pleckstrin Homology Domain and Switches an Epidermal Growth Factor Response to an Invasive Morphogenic Program","year":2003,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Pleckstrin homology domain; Biology; Cell biology; GRB2; Epidermal growth factor; Morphogenesis; Epidermal growth factor receptor; Signal transduction; Signal transducing adaptor protein; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008245448,0.0003167372,0.0004124378,0.00007930181,0.0001663458,0.00001539515,0.0004521569,0.0003748195,0.000005043355],"category_scores_gemma":[0.001985888,0.0002770766,0.0001514186,0.0002330992,0.0004386384,0.00002231035,0.0001703981,0.0001160137,5.183254e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004047361,"about_ca_system_score_gemma":0.0002422933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001206246,"about_ca_topic_score_gemma":0.00005230248,"domain_scores_codex":[0.9973229,0.0009159202,0.0005067277,0.0006545719,0.00012317,0.0004767662],"domain_scores_gemma":[0.9985345,0.000103924,0.0004809747,0.0005157912,0.0002543601,0.0001104429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006730551,0.0002058664,0.00219165,0.00008332109,0.00007966616,0.000004511962,0.000147417,0.0000900814,0.9955237,0.0008663835,0.00001221108,0.0001221385],"study_design_scores_gemma":[0.001098788,0.002051224,0.0006655799,0.00004018117,0.00004381757,0.00001839571,0.00008814339,0.00001521337,0.9934666,0.00207111,0.0001411729,0.0002998427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903374,0.002021254,0.005008916,0.0001686305,0.00006882634,0.002088545,0.0002735189,0.00002368349,0.000009166268],"genre_scores_gemma":[0.9716436,0.00003134925,0.02753562,0.0001207314,0.00001902717,0.0002466304,0.0003478347,0.00004048316,0.00001475231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0225267,"threshold_uncertainty_score":0.9999681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892705079183035,"score_gpt":0.2796328612690279,"score_spread":0.2607058104771975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}