{"id":"W2135921719","doi":"10.15252/emmm.201505047","title":"Antisense‐mediated exon skipping: a therapeutic strategy for titin‐based dilated cardiomyopathy","year":2015,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Medical Research Council; Technische Universität München; Deutsche Forschungsgemeinschaft; National Health and Medical Research Council; Deutsches Zentrum für Herz-Kreislaufforschung","keywords":"Titin; Exon skipping; Frameshift mutation; Exon; Sarcomere; Dilated cardiomyopathy; Biology; Mutation; Cardiomyopathy; Obscurin; Molecular biology; Heart failure; Cell biology; Medicine; Internal medicine; Cancer research; Genetics; Alternative splicing; Myocyte; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990035,0.0002767103,0.0001874775,0.0001747885,0.0001407847,0.0001246965,0.0001838785,0.0002726293,0.0005794463],"category_scores_gemma":[0.00007337335,0.00008494362,0.0001676572,0.00006324512,0.000198586,0.0001230251,0.0001305338,0.0004205953,0.0001386043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001146971,"about_ca_system_score_gemma":0.000149409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819857,"about_ca_topic_score_gemma":0.0004841656,"domain_scores_codex":[0.9999475,0.00001112977,0.000003783033,0.00001371751,0.00001330008,0.00001037876],"domain_scores_gemma":[0.9999771,0.000005506901,0.000007386679,0.000002398328,0.000002656351,0.000005023931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007743372,0.00006871451,0.0001000391,0.00005381174,0.000006722559,0.0001480835,0.0000195693,0.0001222575,0.9910342,0.0005397802,0.0001139886,0.007715488],"study_design_scores_gemma":[0.0002569114,0.004755585,0.003355216,0.0000418288,0.000115973,0.003002936,0.00005607858,0.002193355,0.9646013,0.000643125,0.02095255,0.00002512255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9481931,0.01058109,0.0340871,0.0009305815,0.000382775,0.000174081,0.0001850312,0.0003219424,0.005144392],"genre_scores_gemma":[0.9782302,0.007302831,0.0110468,0.0002608591,0.00007428155,0.00009419882,0.0001703755,0.00002460052,0.00279572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005794463,"threshold_uncertainty_score":0.001938462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06774321801274284,"score_gpt":0.3255900194095654,"score_spread":0.2578468013968226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}