{"id":"W2135956175","doi":"10.1124/jpet.104.070805","title":"Inhibitory Profile of SEA0400 [2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline] Assessed on the Cardiac Na+-Ca2+ Exchanger, NCX1.1","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Boniface Hospital","funders":"","keywords":"Isotopes of calcium; Ion exchange; Kinetics; Chemistry; Biophysics; Ion; Physics; Calcium; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000455188,0.0001678324,0.0002325641,0.00006714572,0.000125419,0.0000116289,0.0001322249,0.0001709858,0.0001024548],"category_scores_gemma":[0.00001102364,0.0001189213,0.0001556042,0.00008462129,0.0002001648,0.00001235821,0.00005033508,0.0002209802,0.000002639498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004629952,"about_ca_system_score_gemma":0.0001175624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000190513,"about_ca_topic_score_gemma":1.374243e-7,"domain_scores_codex":[0.9988909,0.0002342106,0.0003547303,0.0001564519,0.0001951785,0.0001685689],"domain_scores_gemma":[0.9993044,0.00005211185,0.0003181634,0.0001081727,0.0001539008,0.00006320874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008504867,0.0003246254,0.00006625762,0.00001077827,0.0002575599,0.000002799682,0.0004074379,0.0002247797,0.9949804,0.0002461189,0.001650237,0.0009785265],"study_design_scores_gemma":[0.001655867,0.001334492,0.0001485234,0.00001464443,0.00007130828,0.00002767507,0.000777868,0.0000628758,0.9820883,0.00008163921,0.01361735,0.0001194936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904983,0.00481268,0.0006518444,0.0009371247,0.002512262,0.0002255893,0.00001122696,0.000005829394,0.0003451348],"genre_scores_gemma":[0.9956656,0.0006019631,0.0004667551,0.001911849,0.001151797,0.00001252587,0.000009499681,0.00002072888,0.0001592693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01289213,"threshold_uncertainty_score":0.4849471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03095703948336659,"score_gpt":0.3284186927991217,"score_spread":0.2974616533157551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}