{"id":"W2135964866","doi":"10.1128/aac.00530-10","title":"Cationic Amphiphiles, a New Generation of Antimicrobials Inspired by the Natural Antimicrobial Peptide Scaffold","year":2010,"lang":"en","type":"review","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":297,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Amphiphile; Antimicrobial; Antimicrobial peptides; Bacteria; Cationic polymerization; Antibacterial activity; Combinatorial chemistry; Biology; Antibacterial agent; Peptide; Chemistry; Computational biology; Biochemistry; Microbiology; Antibiotics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002635944,0.000839986,0.000697559,0.00112403,0.0002193412,0.0006020307,0.0004732907,0.0008046696,0.0008846089],"category_scores_gemma":[0.000206142,0.0002036769,0.0002031651,0.0008861552,0.000477643,0.001114724,0.0004621787,0.001053572,0.001118739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003595078,"about_ca_system_score_gemma":0.0003668911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000251286,"about_ca_topic_score_gemma":0.0003888964,"domain_scores_codex":[0.9999033,0.00001407523,0.000008917455,0.00002103331,0.00004062943,0.00001199991],"domain_scores_gemma":[0.9999396,0.0000178615,0.00001341447,0.000002477528,0.00001449743,0.00001208959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001043476,0.0001322844,0.0002170207,0.005886339,0.00004723653,0.0006136034,0.00009381303,0.0007592394,0.09621581,0.008960611,0.009905107,0.8770646],"study_design_scores_gemma":[0.00003672866,0.0002841482,0.0006441046,0.0004557578,0.00003547825,0.002781448,0.00005196483,0.0003468486,0.02200126,0.001856393,0.9714738,0.00003205383],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001915919,0.9931456,0.001801536,0.0002169024,0.0002448835,0.0000155128,0.00002009812,0.00003526892,0.00260433],"genre_scores_gemma":[0.009460257,0.9834234,0.002740565,0.0002950977,0.0002089007,0.00004696168,0.00007264389,0.000006717645,0.003745547],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00112403,"threshold_uncertainty_score":0.002959371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03026463541778584,"score_gpt":0.2757909325457954,"score_spread":0.2455262971280096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}