{"id":"W2135964866","doi":"10.1128/aac.00530-10","title":"Cationic Amphiphiles, a New Generation of Antimicrobials Inspired by the Natural Antimicrobial Peptide Scaffold","year":2010,"lang":"en","type":"review","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":297,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Amphiphile; Antimicrobial; Antimicrobial peptides; Bacteria; Cationic polymerization; Antibacterial activity; Combinatorial chemistry; Biology; Antibacterial agent; Peptide; Chemistry; Computational biology; Biochemistry; Microbiology; Antibiotics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.000394872,0.001237262,0.002625191,0.0002898284,0.0007362734,0.0002499677,0.001058367,0.001363088,0.0004575196],"category_scores_gemma":[0.00003844965,0.0008944844,0.0009859619,0.0004445637,0.001087637,0.0003084043,0.0002709168,0.00129803,0.0001321498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008175606,"about_ca_system_score_gemma":0.0007500342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009241102,"about_ca_topic_score_gemma":0.000195381,"domain_scores_codex":[0.9959225,0.0003522503,0.001567083,0.001129115,0.0001178609,0.0009111578],"domain_scores_gemma":[0.9971384,0.0001783418,0.001523842,0.0009207972,0.0001516927,0.00008692236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004737474,0.0002311308,0.00001777162,0.001077587,0.0006695781,0.000002248551,0.0002502874,4.848923e-7,0.141533,0.0001153817,0.5549855,0.3010697],"study_design_scores_gemma":[0.001517744,0.00007975028,0.00001939131,0.002124126,0.0007102471,0.0003263594,0.00001652617,0.000001773997,0.02984704,0.00001023172,0.9643964,0.0009503769],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0296224,0.960103,0.00008480114,0.002201676,0.003361695,0.002721641,0.001466151,0.0001739504,0.0002646882],"genre_scores_gemma":[0.006460018,0.9761969,0.0002380696,0.003275407,0.0006588697,0.00001985401,0.002952806,0.0002075135,0.009990507],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4094109,"threshold_uncertainty_score":0.9999334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03026463541778584,"score_gpt":0.2757909325457954,"score_spread":0.2455262971280096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}