{"id":"W2136103397","doi":"10.1515/bc.2008.085","title":"Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration","year":2008,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"Craig H. Neilsen Foundation; National Multiple Sclerosis Society; National Institute of Neurological Disorders and Stroke; U.S. Department of Health and Human Services","keywords":"Neurodegeneration; Multiple sclerosis; Kallikrein; Medicine; Neuroscience; Chemistry; Biology; Internal medicine; Biochemistry; Disease; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005507531,0.0001672476,0.0002517916,0.00001107705,0.0001686781,0.00001434311,0.0000461914,0.0001975244,0.0001456883],"category_scores_gemma":[0.0002783806,0.0001130026,0.00005179686,0.0001021551,0.0002193319,0.00004437723,0.00003287823,0.0001593741,0.000002890449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003021356,"about_ca_system_score_gemma":0.00005959296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000504129,"about_ca_topic_score_gemma":0.000002370474,"domain_scores_codex":[0.9991239,0.00002017982,0.0001755012,0.0003419879,0.000132738,0.0002056726],"domain_scores_gemma":[0.9994367,0.0000559863,0.0001306078,0.0001345377,0.00009939722,0.0001428013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002234665,0.0003267111,0.7298706,0.0000571752,0.00007298616,0.000146523,0.0001181601,0.000003116967,0.2664904,0.000004124834,0.0004603466,0.002226454],"study_design_scores_gemma":[0.00139103,0.0002258116,0.8165188,0.000121166,0.00002755338,0.0001347722,0.00002615497,0.0002601412,0.1807721,0.00001112709,0.0003475566,0.0001637742],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977028,0.001191772,0.00001259679,0.0002957613,0.00001827216,0.0002267975,0.00002951454,0.00013517,0.000387321],"genre_scores_gemma":[0.9983288,0.0001205941,0.0002596216,0.0002547367,0.0001564653,0.00003128357,0.000287102,0.0000134396,0.0005479309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08664823,"threshold_uncertainty_score":0.4608112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05669954624020457,"score_gpt":0.2264521120633335,"score_spread":0.1697525658231289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}