{"id":"W2136114404","doi":"10.1128/mcb.20.10.3442-3448.2000","title":"Deficient Gene Expression in Protein Kinase Inhibitor α Null Mutant Mice","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Andrew W. Mellon Foundation; Foundation for the National Institutes of Health","keywords":"Biology; Protein kinase A; Protein subunit; Mutant; Molecular biology; CREB; Gene knockout; Gene isoform; Cyclic AMP Response Element-Binding Protein; Cell biology; Kinase; Gene; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005068392,0.00184026,0.0007630516,0.002336773,0.0006611679,0.001154197,0.001241215,0.001696483,0.008281034],"category_scores_gemma":[0.0005086624,0.001015025,0.0007543269,0.0006736809,0.001621387,0.0007601981,0.0007137014,0.002491641,0.003550658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006612319,"about_ca_system_score_gemma":0.0004686518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006187229,"about_ca_topic_score_gemma":0.0006971729,"domain_scores_codex":[0.9992938,0.00006865261,0.00009358158,0.0002793044,0.0001587707,0.000105823],"domain_scores_gemma":[0.9990434,0.0001258318,0.0003835583,0.0001015118,0.00005661669,0.0002890028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003798376,0.0001671499,0.0003154292,0.00007483888,0.0000233913,0.0008437211,0.00007310301,0.0001500524,0.9937935,0.001442754,0.000310242,0.002426046],"study_design_scores_gemma":[0.0007879841,0.0013464,0.007894637,0.0001631766,0.0002195288,0.01301852,0.0002073723,0.003356398,0.9382288,0.002006846,0.03268708,0.00008328852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9311218,0.003371055,0.03529491,0.001418731,0.0005510401,0.000578074,0.01156699,0.003064648,0.01303281],"genre_scores_gemma":[0.8956268,0.006003845,0.03201666,0.0007053341,0.0002123425,0.0009571004,0.008546871,0.00145302,0.05447799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008281034,"threshold_uncertainty_score":0.02770281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00540128722107484,"score_gpt":0.2116712118520214,"score_spread":0.2062699246309465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}