{"id":"W2136114404","doi":"10.1128/mcb.20.10.3442-3448.2000","title":"Deficient Gene Expression in Protein Kinase Inhibitor α Null Mutant Mice","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Andrew W. Mellon Foundation; Foundation for the National Institutes of Health","keywords":"Biology; Protein kinase A; Protein subunit; Mutant; Molecular biology; CREB; Gene knockout; Gene isoform; Cyclic AMP Response Element-Binding Protein; Cell biology; Kinase; Gene; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137386,0.0002142228,0.0001868343,0.00007781832,0.00007733145,0.00001931772,0.0001213176,0.000268733,0.0001189218],"category_scores_gemma":[0.00002431048,0.0002002608,0.00008115846,0.0001152941,0.0001096686,0.000003396837,0.00008301512,0.0001174718,0.0000173532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001382288,"about_ca_system_score_gemma":0.00003925598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002408534,"about_ca_topic_score_gemma":0.000007133041,"domain_scores_codex":[0.9985611,0.000188379,0.0002737946,0.0005466483,0.00008815779,0.0003419242],"domain_scores_gemma":[0.9995108,0.000003574326,0.00005333172,0.0002881509,0.00003145359,0.0001126946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001226771,0.00008412942,0.0001729396,0.0000156145,0.000008084189,0.00006722316,0.00002568741,0.00009086275,0.9942051,0.0001565092,0.00001116376,0.005039996],"study_design_scores_gemma":[0.0008203821,0.0002059123,0.00005631481,0.00003393227,0.000007057796,0.0000236753,0.00001647117,0.0001275449,0.98458,0.000271662,0.01360236,0.0002547153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869891,0.005552039,0.006431089,0.00009293673,0.00003944881,0.0004105856,0.00001422075,0.00001588322,0.0004547188],"genre_scores_gemma":[0.9974254,0.00007834886,0.001640512,0.000242485,0.00007775661,0.00006719033,0.0002340413,0.00002465413,0.0002095876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01359119,"threshold_uncertainty_score":0.8166397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00540128722107484,"score_gpt":0.2116712118520214,"score_spread":0.2062699246309465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}