{"id":"W2136128469","doi":"10.1016/j.bmcl.2006.05.019","title":"Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Valeant Pharmaceuticals International","keywords":"Chemistry; Stereochemistry; Combinatorial chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002052545,0.0003910573,0.000370132,0.00004614616,0.00008045275,0.00002608078,0.0004149017,0.0002780708,0.00006035763],"category_scores_gemma":[0.00008426093,0.0003565355,0.000216357,0.0001620536,0.000321556,0.00001251494,0.0001692871,0.0002049561,0.00001747621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005351601,"about_ca_system_score_gemma":0.0001573422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002220649,"about_ca_topic_score_gemma":0.000007959411,"domain_scores_codex":[0.9978098,0.00003915636,0.0005672465,0.0006137666,0.0004874349,0.0004825412],"domain_scores_gemma":[0.9988955,0.00002141684,0.0002777947,0.0006142746,0.00006588612,0.0001251352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001007431,0.0001094619,0.001830913,0.0001432104,0.0000668138,0.00005276725,0.00002795098,0.00000802523,0.9891943,0.00004372564,0.008243545,0.0001784987],"study_design_scores_gemma":[0.0008130431,0.0001119962,0.002539325,0.00007906529,0.00007523212,0.0001376484,0.0001311576,0.000006698913,0.990511,0.00004782111,0.005169204,0.0003778189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923891,0.001387817,0.000495628,0.001304556,0.0003426916,0.0001664599,0.00003743722,0.00003517246,0.003841077],"genre_scores_gemma":[0.9964358,0.00008832894,0.00009230102,0.000676849,0.001364829,0.00001409885,0.0003608613,0.00005372766,0.0009132412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004046603,"threshold_uncertainty_score":0.9998887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003618601174519771,"score_gpt":0.1866724510114279,"score_spread":0.1830538498369082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}