{"id":"W2136143258","doi":"10.1128/aac.49.8.3153-3162.2005","title":"Mechanism of Inhibition of Vaccinia Virus DNA Polymerase by Cidofovir Diphosphate","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"U.S. Army Medical Research Acquisition Activity; National Eye Institute; Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; University of Alberta","keywords":"Vaccinia; DNA polymerase; Biology; Polymerase; Virology; Poxviridae; Primer (cosmetics); Proofreading; Exonuclease; Processivity; Virus; DNA polymerase II; Orthopoxvirus; Molecular biology; DNA; Reverse transcriptase; Biochemistry; Chemistry; Polymerase chain reaction; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004479604,0.0009752371,0.0005964899,0.0003697019,0.0002273896,0.0006288239,0.0006393809,0.0007932898,0.001257854],"category_scores_gemma":[0.0003635201,0.0003905363,0.0006802198,0.0001418202,0.0002879268,0.0004438154,0.0003535694,0.00067408,0.0006764495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005490891,"about_ca_system_score_gemma":0.000314641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004461992,"about_ca_topic_score_gemma":0.0002883017,"domain_scores_codex":[0.9995534,0.00009810299,0.00004303865,0.0001336346,0.00008623009,0.00008563389],"domain_scores_gemma":[0.9998391,0.00007335984,0.00003102485,0.00001512176,0.00002270883,0.0000186432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000168811,0.00004274737,0.0003009655,0.0002922091,0.00002760207,0.0002021894,0.00003191387,0.0005367508,0.9911605,0.0009484331,0.0001195209,0.006168291],"study_design_scores_gemma":[0.00002074441,0.0002793661,0.0004942677,0.000012498,0.00001412971,0.000270339,0.000007791524,0.001111753,0.994926,0.0001372352,0.002717423,0.000008464638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8234597,0.07859784,0.07332782,0.0007222907,0.0006812448,0.000901669,0.002208749,0.0005401783,0.01956047],"genre_scores_gemma":[0.9768876,0.008164372,0.01056957,0.0001551392,0.00004567406,0.0001996095,0.0005277766,0.00003126754,0.00341895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001257854,"threshold_uncertainty_score":0.004207969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213912366941687,"score_gpt":0.2740613993831438,"score_spread":0.2619222757137269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}