{"id":"W2136159122","doi":"10.1073/pnas.1011477108","title":"Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; National Cancer Institute; National Institute of General Medical Sciences; National Institute of Mental Health; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Translation (biology); EIF4E; Heterotrimeric G protein; Biology; Cell biology; Small molecule; Eukaryotic translation initiation factor 4 gamma; Signal transduction; Messenger RNA; Biochemistry; G protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001115364,0.0002725103,0.0003446837,0.0002751618,0.0001397063,0.0002595232,0.0001903699,0.0001879561,0.0008993783],"category_scores_gemma":[0.00008899577,0.0001104862,0.0001815268,0.0001716372,0.0001317424,0.0001177967,0.0001146083,0.0004659753,0.0001938988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002419425,"about_ca_system_score_gemma":0.0001862547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003908458,"about_ca_topic_score_gemma":0.001413049,"domain_scores_codex":[0.9999442,0.000007883822,0.000005858687,0.000008321506,0.00001549883,0.000018207],"domain_scores_gemma":[0.9999671,0.00001017406,0.000008914419,0.000003334987,0.000003528477,0.000006896936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004109112,0.0002756879,0.0002487212,0.0001032658,0.00002639665,0.00008017926,0.00001500521,0.001060112,0.9839634,0.0002977814,0.0003001429,0.01321843],"study_design_scores_gemma":[0.0002263218,0.002093004,0.001700438,0.000009341346,0.00005025766,0.0001942239,0.00001358689,0.002359592,0.988597,0.00008520896,0.004661369,0.000009708574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925308,0.00311997,0.001479434,0.0001728877,0.0000512518,0.00006362526,0.000252142,0.000135418,0.002194412],"genre_scores_gemma":[0.9942819,0.002460273,0.001309319,0.00006793837,0.00001420631,0.000042117,0.0003082873,0.0000129518,0.001502981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008993783,"threshold_uncertainty_score":0.003008723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04266309798845355,"score_gpt":0.2914215330921663,"score_spread":0.2487584351037127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}