{"id":"W2136169984","doi":"10.1073/pnas.0401870101","title":"Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond","year":2004,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Force Microscopy Techniques and Applications","field":"Physics and Astronomy","cited_by":324,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute","keywords":"Chemistry; Dissociation (chemistry); Force spectroscopy; Kinetics; Biophysics; Selectin; Bond strength; Stereochemistry; Crystallography; Adhesion; Molecule; Adhesive; Physical chemistry; Biology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006322957,0.00005433491,0.00009462512,0.00006379024,0.0001601837,0.0000203387,0.0002048961,0.00003015802,0.000001822629],"category_scores_gemma":[0.00002774332,0.00004065624,0.00003056533,0.0003884258,0.00008646788,0.0001908368,0.00006917018,0.000131529,1.941094e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003014407,"about_ca_system_score_gemma":0.0000200623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005363235,"about_ca_topic_score_gemma":1.316775e-7,"domain_scores_codex":[0.999273,0.000001091285,0.000208204,0.0001439914,0.0002796007,0.00009413956],"domain_scores_gemma":[0.9996486,0.00004484212,0.0002291161,0.00000411132,0.00005672463,0.00001658163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000001368473,0.00002151806,0.03717674,0.000006672505,0.000002542566,2.674922e-10,0.0001253099,0.00006474084,0.5794746,0.382762,0.000008747901,0.0003556794],"study_design_scores_gemma":[0.0001392304,0.00001478809,0.03041451,0.00007228983,0.00000432057,1.653794e-7,0.0001328997,0.0007221217,0.5678715,0.4005775,0.000007702384,0.00004290257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981828,0.00001185573,0.0001266428,0.000785305,0.000002091582,0.0001361276,0.000008310444,0.000007410818,0.0007394248],"genre_scores_gemma":[0.9959768,0.000002464446,0.003937795,0.00001998522,0.00004433184,0.00001159438,2.625969e-7,0.000002559628,0.000004171826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0178155,"threshold_uncertainty_score":0.1657913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299911582384915,"score_gpt":0.3218288320884606,"score_spread":0.2918376738499691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}