{"id":"W2136179374","doi":"10.1074/jbc.m407309200","title":"Glucocorticoid Ligands Specify Different Interactions with NF-κB by Allosteric Effects on the Glucocorticoid Receptor DNA Binding Domain","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"PerkinElmer Biosignal","funders":"","keywords":"Glucocorticoid receptor; Transactivation; Chromatin immunoprecipitation; DNA-binding domain; Nuclear receptor; Glucocorticoid; Nuclear receptor coactivator 2; Electrophoretic mobility shift assay; Cell biology; Chemistry; NF-κB; Hormone response element; Biology; Transcription factor; Molecular biology; Promoter; Signal transduction; Biochemistry; Estrogen receptor; Endocrinology; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001765176,0.0003324172,0.0002842454,0.0001504116,0.0001921331,0.000468697,0.0002751917,0.0002570054,0.002577197],"category_scores_gemma":[0.0001987532,0.0002229499,0.0003928594,0.0001261097,0.0002610243,0.0001870253,0.0002752534,0.0005369976,0.0007949364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003003459,"about_ca_system_score_gemma":0.00013165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000322629,"about_ca_topic_score_gemma":0.0007170202,"domain_scores_codex":[0.9996948,0.00008181009,0.00002514036,0.0000549468,0.00008591826,0.00005733256],"domain_scores_gemma":[0.9998807,0.00003007708,0.00003357668,0.00001968868,0.000009731678,0.00002616084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001066831,0.00001687153,0.0001284364,0.00002455454,0.000003307212,0.00001559547,0.000009355643,0.00004006281,0.9986857,0.0001102126,0.00001842516,0.0008408984],"study_design_scores_gemma":[0.00002615844,0.0002279718,0.00408878,0.00001009637,0.00000980483,0.0002541023,0.00003187405,0.0005891991,0.9916025,0.00006156094,0.003088284,0.000009745298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898528,0.003929994,0.003421569,0.0001441967,0.00003549445,0.00002803285,0.0002758276,0.0001209661,0.002191058],"genre_scores_gemma":[0.9941177,0.0009413143,0.002743722,0.00007322519,0.00001245975,0.00002967132,0.0003078841,0.00002786454,0.001746219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002577197,"threshold_uncertainty_score":0.008621573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007522510504236235,"score_gpt":0.2214798573211761,"score_spread":0.2139573468169399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}