{"id":"W2136212424","doi":"10.1101/gad.1363206","title":"Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways","year":2006,"lang":"en","type":"review","venue":"Genes & Development","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":322,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Biology; Signal transduction; Proto-Oncogene Proteins c-akt; Cell biology; Protein kinase B; TOR signaling; PI3K/AKT/mTOR pathway; Nutrient sensing; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000466262,0.0003225862,0.0004345236,0.00005910469,0.0002764956,0.00006160105,0.0002598366,0.0003250933,0.00001080753],"category_scores_gemma":[0.00001019312,0.0002506008,0.00008588762,0.00009910041,0.0001154027,0.000005578378,0.0001386518,0.0001631692,0.000004273938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008798621,"about_ca_system_score_gemma":0.0003419349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001927695,"about_ca_topic_score_gemma":0.00003152297,"domain_scores_codex":[0.9985256,0.0001918458,0.0004640211,0.0004332476,0.0001763151,0.0002090319],"domain_scores_gemma":[0.9992108,0.00004763795,0.0002538257,0.00034776,0.00008486103,0.00005515596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005138439,0.00001217005,0.0001117576,0.0007557846,0.0001454088,3.762679e-7,0.00007478156,0.000002328313,0.0008130248,0.00001214454,0.0007574082,0.9973097],"study_design_scores_gemma":[0.0001622295,0.00004568457,0.0003674237,0.0005306596,0.0002181634,0.00001875769,0.00001391534,0.000002067237,0.003977012,0.00003764337,0.9943011,0.0003253003],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005921585,0.9921089,0.00107428,0.00006694788,0.0001175056,0.0005560858,0.0000415127,0.00001702576,0.00009619848],"genre_scores_gemma":[0.006005778,0.9899042,0.001693194,0.00003335708,0.0003707672,0.0002407583,0.0015161,0.0000467518,0.0001891452],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9969844,"threshold_uncertainty_score":0.9999946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03859388960144575,"score_gpt":0.289630869235468,"score_spread":0.2510369796340223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}