{"id":"W2136217146","doi":"10.1111/cen.12164","title":"What is the evidence in humans that <scp>DNA</scp> methylation changes link events in utero and later life disease?","year":2013,"lang":"en","type":"review","venue":"Clinical Endocrinology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"British Heart Foundation","keywords":"DNA methylation; Epigenetics; Disease; In utero; Biomarker; Biology; Chromatin; Epigenesis; Methylation; Bioinformatics; Gene expression; Genetics; Gene; Medicine; Pregnancy; Internal medicine; Fetus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006586136,0.0003941791,0.0009820575,0.000148801,0.00005317315,0.00006259769,0.0004486909,0.0006611593,0.00002264414],"category_scores_gemma":[0.001511962,0.0002792855,0.0002754056,0.0001269436,0.0002267819,0.00002273891,0.0004840788,0.0005849561,0.00005174347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002213041,"about_ca_system_score_gemma":0.0001525864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003232528,"about_ca_topic_score_gemma":0.0001906279,"domain_scores_codex":[0.9963512,0.001158846,0.0009283405,0.0009140486,0.0001502701,0.000497281],"domain_scores_gemma":[0.9973579,0.00122971,0.0004358181,0.0007359128,0.00006370495,0.0001769756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000009784255,0.00008924064,0.02338389,0.001226298,0.0001255375,0.00001583719,0.00008080861,0.000002428947,0.00005219254,0.00003188441,0.0002672505,0.9747149],"study_design_scores_gemma":[0.0005283729,0.0002893032,0.04278624,0.002645108,0.0002139985,0.000004023086,0.00004870653,0.00001869695,0.0001643018,0.001437614,0.9516131,0.0002505611],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04431405,0.9520836,0.00002353141,0.001680773,0.000721474,0.001134578,0.00001051038,0.000008162684,0.00002327552],"genre_scores_gemma":[0.008804487,0.9888451,0.00005056757,0.0007400128,0.000509248,0.0004054338,0.0001375056,0.00004411337,0.0004634922],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9744643,"threshold_uncertainty_score":0.9999659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1801379612787324,"score_gpt":0.4215942625112166,"score_spread":0.2414563012324842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}