{"id":"W2136241579","doi":"10.1139/cjc-2012-0319","title":"Allosteric <i>N-</i>acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase — Acylsulfonamides and acylsulfamides as carboxylic acid replacements","year":2013,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; NS5B; Carboxylic acid; ADME; Allosteric regulation; Stereochemistry; RNA polymerase; Hepatitis C virus; Biochemistry; Enzyme; Virology; Virus; Genotype; RNA; In vitro; Hepacivirus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500483,0.0002354045,0.0002003815,0.0001094977,0.000085432,0.0001548767,0.00023892,0.0001288557,0.001371396],"category_scores_gemma":[0.000123531,0.00007291112,0.0001408104,0.00009386281,0.0001343422,0.0001108421,0.0001389506,0.0002738634,0.0002515535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002210268,"about_ca_system_score_gemma":0.0001585417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009371628,"about_ca_topic_score_gemma":0.002706653,"domain_scores_codex":[0.9999456,0.00001201136,0.000003869799,0.000007638891,0.00001484088,0.0000159465],"domain_scores_gemma":[0.9999593,0.000006824681,0.00001540455,0.000003183618,0.000006438608,0.000008797463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009483247,0.000149946,0.0005419165,0.0001395194,0.00001220879,0.0001849989,0.00004335674,0.001808992,0.9684885,0.0007902955,0.0004601328,0.02643175],"study_design_scores_gemma":[0.0007355092,0.007054147,0.005504275,0.00003178134,0.00007422105,0.001108597,0.00006455673,0.008340314,0.9603271,0.000304353,0.01641899,0.00003621698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834933,0.004582933,0.004319608,0.0001270823,0.00005969854,0.0001148448,0.0002392553,0.0002073317,0.00685598],"genre_scores_gemma":[0.9938548,0.001795206,0.002135457,0.00006134621,0.0000193997,0.00002607935,0.0001597609,0.000009476822,0.001938395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001371396,"threshold_uncertainty_score":0.00458771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100829346576997,"score_gpt":0.2452447405871393,"score_spread":0.2342364471213693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}