{"id":"W2136405771","doi":"10.1158/1535-7163.mct-05-0229","title":"Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor","year":2005,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"AP site; Molecular biology; Melanoma; DNA-(apurinic or apyrimidinic site) lyase; Apoptosis; Transcription factor; Biology; DNA damage; Cancer research; Chemistry; Resveratrol; Base excision repair; DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382855,0.0002987817,0.0001578317,0.0002078108,0.0001018153,0.0001416626,0.0001003454,0.0002812058,0.000750008],"category_scores_gemma":[0.0001005571,0.0001427356,0.000268753,0.0001054147,0.0001426685,0.000153786,0.00007587046,0.0003730237,0.0002043956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001570762,"about_ca_system_score_gemma":0.0000964088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004178225,"about_ca_topic_score_gemma":0.0003792284,"domain_scores_codex":[0.9999094,0.00001775086,0.000009104194,0.00002795614,0.00001786146,0.00001799734],"domain_scores_gemma":[0.9999485,0.000007946819,0.0000155393,0.000006562648,0.00000988083,0.00001158516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004911739,0.0000147357,0.0001681247,0.00001559646,0.000002790194,0.0000284905,0.0000112142,0.00001076243,0.9993296,0.00002033128,0.000005240532,0.0003441437],"study_design_scores_gemma":[0.0000146322,0.000555454,0.00921743,0.00000382503,0.00002679046,0.0005396236,0.00003301342,0.0004258697,0.9881889,0.00004595938,0.0009444388,0.000004171944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958817,0.002316526,0.001292786,0.00003629562,0.00001527703,0.00001560168,0.0001238785,0.00002686726,0.0002910835],"genre_scores_gemma":[0.9967962,0.0009426074,0.001063041,0.00001613109,0.000004782942,0.00001742191,0.0002138982,0.000004759408,0.0009412703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000750008,"threshold_uncertainty_score":0.002508998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258426550445587,"score_gpt":0.3051051727510787,"score_spread":0.2925209072466229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}