{"id":"W2136405771","doi":"10.1158/1535-7163.mct-05-0229","title":"Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor","year":2005,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"AP site; Molecular biology; Melanoma; DNA-(apurinic or apyrimidinic site) lyase; Apoptosis; Transcription factor; Biology; DNA damage; Cancer research; Chemistry; Resveratrol; Base excision repair; DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000219008,0.000169593,0.0001760352,0.00005736774,0.00008204974,0.00002041529,0.0004422719,0.0001355901,0.000009725018],"category_scores_gemma":[0.00001110285,0.0001104543,0.0001238765,0.0001768976,0.0001443879,0.0000113849,0.0000939476,0.0001689392,1.852131e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002222444,"about_ca_system_score_gemma":0.00007406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007164672,"about_ca_topic_score_gemma":0.0002276502,"domain_scores_codex":[0.9985573,0.0002572181,0.000492692,0.0002596079,0.0002560669,0.0001771308],"domain_scores_gemma":[0.998996,0.00001443188,0.0002207939,0.0006749802,0.00006893263,0.00002487769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005662931,0.0001248636,0.001887115,0.00002781933,0.00003911024,4.579193e-7,0.0009873816,0.003731428,0.9907548,0.0001578474,0.000003766716,0.002228717],"study_design_scores_gemma":[0.0006894781,0.0001256153,0.02711344,0.00004631702,0.00005523325,0.000004962403,0.000321697,0.0005918529,0.9703032,0.0001555254,0.0004750276,0.0001175985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947491,0.00350178,0.000769566,0.0003617863,0.0001072568,0.0004343256,0.00003324654,0.000003374112,0.00003959061],"genre_scores_gemma":[0.9991776,0.0003121278,0.00005048893,0.0002829073,0.0000750609,0.00003934763,0.00001093483,0.00002543494,0.00002614301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02522632,"threshold_uncertainty_score":0.4504198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258426550445587,"score_gpt":0.3051051727510787,"score_spread":0.2925209072466229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}