{"id":"W2136458559","doi":"10.18433/j3r015","title":"Poly[N-(2-aminoethyl)ethyleneimine] as a New Non-Viral Gene Delivery Carrier: The Effect of Two Protonatable Nitrogens in the Monomer Unit on Gene Delivery Efficiency","year":2014,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Zeta potential; Gene delivery; Monomer; Ionic strength; HeLa; Nuclear chemistry; HEPES; Polymer chemistry; Polymer; Transfection; Organic chemistry; Biochemistry; Nanoparticle; Chemical engineering; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000205187,0.0002473524,0.0001818525,0.0001145454,0.00006584618,0.0002409583,0.000215341,0.00032221,0.0003127506],"category_scores_gemma":[0.0002071313,0.0001066075,0.0001407746,0.0001101096,0.0001667308,0.0003520229,0.0001226969,0.0002471454,0.0001680844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002030259,"about_ca_system_score_gemma":0.0001065457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002075144,"about_ca_topic_score_gemma":0.0002123916,"domain_scores_codex":[0.9998719,0.00002386177,0.00001013138,0.00004524405,0.00003637955,0.000012513],"domain_scores_gemma":[0.9998724,0.00003470277,0.00004585106,0.000007531473,0.0000182736,0.00002117609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005479758,0.00002191367,0.0001081372,0.00005606428,0.00000464734,0.00003076795,0.000007466139,0.00009318564,0.9979911,0.00002904064,0.000008853272,0.001593966],"study_design_scores_gemma":[0.0000105899,0.0004967331,0.0008621891,0.000003320899,0.00001583606,0.000158037,0.000004078906,0.0009029738,0.9964944,0.00000846152,0.001038707,0.000004782615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928868,0.002574276,0.003907094,0.00004879658,0.00001561615,0.00002367272,0.00003316059,0.00002845064,0.0004820441],"genre_scores_gemma":[0.9857478,0.001998276,0.00985717,0.00004082618,0.00001327326,0.00003074462,0.0001415752,0.00001909702,0.002151259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00032221,"threshold_uncertainty_score":0.001473069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03064085969232844,"score_gpt":0.3581283958207738,"score_spread":0.3274875361284454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}