{"id":"W2136485284","doi":"10.1002/mus.24698","title":"Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle","year":2015,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"mTORC1; Metformin; P70-S6 Kinase 1; Endocrinology; Skeletal muscle; Internal medicine; Signal transduction; Phosphorylation; Biology; Medicine; Cell biology; PI3K/AKT/mTOR pathway; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002385413,0.0002470624,0.0002830469,0.00005407602,0.00005231998,0.00003172541,0.0001526871,0.0001697788,0.0001024851],"category_scores_gemma":[0.00006243306,0.000221914,0.0001413429,0.000159619,0.00004051542,0.000014066,0.00005499552,0.0001022508,0.00002243546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001108224,"about_ca_system_score_gemma":0.0001320357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006453286,"about_ca_topic_score_gemma":0.0001935082,"domain_scores_codex":[0.9985842,0.0001512637,0.0002334582,0.0004549874,0.0001829052,0.000393251],"domain_scores_gemma":[0.999295,0.0000220116,0.00009135917,0.0003344048,0.00007572786,0.000181502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006699978,0.0003413123,0.0005512253,0.00001332667,0.0001106738,0.00001820531,0.0009704726,0.00007282187,0.724322,0.00001153457,0.008867547,0.2646538],"study_design_scores_gemma":[0.002539611,0.0004890925,0.002452409,0.00001322556,0.0000501432,0.000002142993,0.0004470998,0.00006337946,0.5142413,0.00005992451,0.4792938,0.0003478908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9466026,0.05198188,0.00005967922,0.00002229956,0.0002078569,0.0002727864,0.0000838984,0.00001923455,0.0007497042],"genre_scores_gemma":[0.9966556,0.001392103,0.000172179,0.0003429397,0.0003228512,0.0001193237,0.0002757442,0.00003925513,0.0006799982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4704262,"threshold_uncertainty_score":0.9049392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944151056516688,"score_gpt":0.2629590963048383,"score_spread":0.2435175857396714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}