{"id":"W2136485284","doi":"10.1002/mus.24698","title":"Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle","year":2015,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"mTORC1; Metformin; P70-S6 Kinase 1; Endocrinology; Skeletal muscle; Internal medicine; Signal transduction; Phosphorylation; Biology; Medicine; Cell biology; PI3K/AKT/mTOR pathway; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002416292,0.0003069756,0.0004912466,0.0003669221,0.0001935934,0.0002541644,0.0002449553,0.0003043152,0.0016308],"category_scores_gemma":[0.0001331695,0.0002388107,0.0003490615,0.0002000623,0.0003827768,0.0003061535,0.0002101504,0.0006331801,0.0002341497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003301962,"about_ca_system_score_gemma":0.0002842921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009475856,"about_ca_topic_score_gemma":0.001879816,"domain_scores_codex":[0.9998376,0.00001807903,0.00002230305,0.0000400769,0.00003820228,0.00004363232],"domain_scores_gemma":[0.9997453,0.00001661884,0.000106669,0.00002209497,0.00002367107,0.00008555156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001951997,0.0001205413,0.00142739,0.00004928864,0.00002457526,0.0001269355,0.00002289683,0.00004098173,0.993469,0.00004543914,0.00006245767,0.002658498],"study_design_scores_gemma":[0.0002285205,0.007360524,0.1127868,0.00003823972,0.0001447758,0.0008960363,0.0001673995,0.0007334083,0.8740965,0.0001414727,0.003385558,0.00002079184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997044,0.001558111,0.0004851441,0.00004841824,0.00003536275,0.00001489646,0.0003723803,0.00003154977,0.000410009],"genre_scores_gemma":[0.9947231,0.001193901,0.0009815644,0.0001081084,0.00001648227,0.00005932611,0.0005938946,0.00001865361,0.002304973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0016308,"threshold_uncertainty_score":0.005455613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944151056516688,"score_gpt":0.2629590963048383,"score_spread":0.2435175857396714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}