{"id":"W2136504668","doi":"10.3324/haematol.2013.092411","title":"Higher ratio immune versus constitutive proteasome level as novel indicator of sensitivity of pediatric acute leukemia cells to proteasome inhibitors","year":2013,"lang":"en","type":"article","venue":"Haematologica","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Myeloid leukemia; Leukemia; Proteasome; Bortezomib; Proteasome inhibitor; Medicine; Acute lymphocytic leukemia; Myeloid; Cancer research; Acute leukemia; Immunology; Pharmacology; Multiple myeloma; Biology; Lymphoblastic Leukemia; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510717,0.0002571538,0.0003214644,0.0003138192,0.0001019667,0.0003436312,0.0001167989,0.0001763874,0.00127825],"category_scores_gemma":[0.0001638778,0.0001113785,0.0001489083,0.0003365022,0.0001466335,0.0002149447,0.000169621,0.0004214871,0.0002683541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000158696,"about_ca_system_score_gemma":0.0001053998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002415622,"about_ca_topic_score_gemma":0.0002816716,"domain_scores_codex":[0.9997467,0.00004714071,0.00003005083,0.00005380077,0.00008313388,0.00003904288],"domain_scores_gemma":[0.9998677,0.00003193983,0.00003694831,0.0000158164,0.0000275143,0.00002005105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001527847,0.00004021398,0.002651333,0.00004413543,0.00001020445,0.00003773472,0.00003932654,0.0000718751,0.9947734,0.00004107954,0.0000235009,0.002114344],"study_design_scores_gemma":[0.00001046646,0.000784973,0.04407831,0.00000596463,0.00002874423,0.0004679156,0.00007873391,0.0005529122,0.9523663,0.00004599684,0.001574921,0.000004871226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905489,0.003895094,0.00345937,0.00002896047,0.0000151006,0.00002716359,0.0006967467,0.00006338362,0.001265236],"genre_scores_gemma":[0.9938143,0.001677255,0.002286004,0.00002631801,0.00001431324,0.00005366085,0.001095141,0.0000105711,0.001022241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127825,"threshold_uncertainty_score":0.004276156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02786528550676899,"score_gpt":0.256983544171331,"score_spread":0.229118258664562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}