{"id":"W2136517791","doi":"10.1016/j.jaad.2015.04.011","title":"Secukinumab retreatment-as-needed versus fixed-interval maintenance regimen for moderate to severe plaque psoriasis: A randomized, double-blind, noninferiority trial (SCULPTURE)","year":2015,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":206,"is_retracted":false,"has_abstract":false,"ca_institutions":"XLV Diagnostics (Canada)","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Secukinumab; Plaque psoriasis; Randomized controlled trial; Regimen; Double blind; Psoriasis; Dermatology; Surgery; Placebo; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008171072,0.0004341628,0.002353085,0.0002762777,0.0001700306,0.00002189235,0.0008713719,0.0004072129,0.00002449466],"category_scores_gemma":[0.0005633459,0.0002752118,0.001026432,0.0003458704,0.0006246369,0.0001705657,0.0001738601,0.0005826481,0.00004886054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002280576,"about_ca_system_score_gemma":0.0004638816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001535227,"about_ca_topic_score_gemma":0.00001664894,"domain_scores_codex":[0.9964515,0.001144612,0.001273569,0.0003567604,0.000170206,0.0006033822],"domain_scores_gemma":[0.9960048,0.0009255727,0.002324676,0.0003114991,0.0002793815,0.0001541152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9761262,0.0002615079,0.00007686896,0.00001689702,0.003227612,0.00002527326,0.00126354,0.00007602323,0.001085252,0.001025136,0.01550295,0.001312752],"study_design_scores_gemma":[0.9372306,0.001987332,0.00003328844,0.0001012385,0.001638803,0.003364925,0.001381006,0.0000161443,0.038943,0.0009393115,0.01402706,0.0003372823],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974685,0.001152947,0.000382427,0.01841548,0.002888628,0.001909013,0.00007418967,0.0000298921,0.0004624773],"genre_scores_gemma":[0.9966475,0.0002360455,0.001018754,0.00096181,0.0002492825,0.0001653444,0.0000125044,0.00003783558,0.0006709764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03889557,"threshold_uncertainty_score":0.99997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0436581266930141,"score_gpt":0.3196616556641326,"score_spread":0.2760035289711185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}