{"id":"W2136544661","doi":"10.1111/j.1365-2990.2004.00560.x","title":"No evidence for mutations or altered expression of the <i>Suppressor of Fused</i> gene <i>(SUFU)</i> in primitive neuroectodermal tumours","year":2004,"lang":"en","type":"article","venue":"Neuropathology and Applied Neurobiology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"","keywords":"Biology; Wnt signaling pathway; Sonic hedgehog; Genetics; Loss of heterozygosity; Hedgehog; Hedgehog signaling pathway; Cancer research; Adenomatous polyposis coli; Tumor suppressor gene; Germline mutation; Gene; Mutation; Exon; Molecular biology; Allele; Cancer; Carcinogenesis; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404242,0.0002053261,0.0003440016,0.00005905764,0.00009592488,0.000003154584,0.0002753753,0.0001594849,0.000001630942],"category_scores_gemma":[0.0005289109,0.0001486235,0.00008163243,0.0001188411,0.0006279136,0.00000491263,0.0002725316,0.0001752961,9.063485e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004428418,"about_ca_system_score_gemma":0.00009280137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002827584,"about_ca_topic_score_gemma":0.00001138535,"domain_scores_codex":[0.9984872,0.0002281667,0.0004076982,0.0005347721,0.00005555898,0.0002866492],"domain_scores_gemma":[0.999019,0.0002769679,0.000243378,0.000333476,0.00009129165,0.00003594545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001106658,0.0001026266,0.0014655,0.00005597157,0.000005826506,0.000007278633,0.0001277875,0.0007784068,0.9961529,0.0001281583,0.0000284017,0.00004051184],"study_design_scores_gemma":[0.001458985,0.000837469,0.02509869,0.00003649342,0.00002710329,0.0001095246,0.00002157831,0.000003773744,0.972082,0.00007999267,0.0001226921,0.0001217387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981518,0.0001593495,0.0004025921,0.0001838939,0.0002750597,0.0006312316,0.00008564283,0.000009772349,0.0001006304],"genre_scores_gemma":[0.9983143,0.0001380218,0.0005878596,0.0006878274,0.00007796475,0.0001236337,0.00001874075,0.00002549301,0.00002615366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02407092,"threshold_uncertainty_score":0.6060691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03442818175087439,"score_gpt":0.2801586144471417,"score_spread":0.2457304326962673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}