{"id":"W2136553172","doi":"10.1073/pnas.1211391110","title":"Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3 <sup>+</sup> regulatory T cells","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Biology; Nod; FOXP3; Major histocompatibility complex; NOD mice; MHC class II; T cell; Regulatory T cell; MHC class I; CD8; Immunology; Cell biology; IL-2 receptor; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174695,0.0003354058,0.0001718917,0.0001683523,0.00007360811,0.0002840447,0.0001145006,0.0001482944,0.001744665],"category_scores_gemma":[0.00007411093,0.0001159747,0.0001292914,0.0000744711,0.0002020423,0.0001497898,0.0001558315,0.000653672,0.0004142719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000115734,"about_ca_system_score_gemma":0.0001104573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001550665,"about_ca_topic_score_gemma":0.0002912142,"domain_scores_codex":[0.9998366,0.00002534439,0.00001354213,0.00004243392,0.00003673432,0.00004527474],"domain_scores_gemma":[0.9998191,0.00001896569,0.0000630638,0.00001689903,0.00001201174,0.00006992466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007316349,0.00001550057,0.0001752025,0.000009865256,0.000001251619,0.00001731834,0.000003462559,0.00001273013,0.9991886,0.00002766439,0.000008229385,0.0004669689],"study_design_scores_gemma":[0.00004459642,0.0008034892,0.006787799,0.000009338677,0.00001628826,0.0004070247,0.00003705397,0.0005268541,0.9897708,0.00004919183,0.001543973,0.000003701302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970189,0.0005878948,0.001230825,0.00003658378,0.00001874447,0.000008550833,0.00009349221,0.00005090584,0.0009541914],"genre_scores_gemma":[0.9958402,0.0005233137,0.001336374,0.00005344686,0.00002476885,0.00001368991,0.0002095463,0.00002675777,0.001971978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001744665,"threshold_uncertainty_score":0.005836487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009487461054819065,"score_gpt":0.2323102195579297,"score_spread":0.2228227585031107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}