{"id":"W2136559746","doi":"10.1093/ckj/sfu029","title":"A severe phenotype of Gitelman syndrome with increased prostaglandin excretion and favorable response to indomethacin","year":2014,"lang":"en","type":"article","venue":"Clinical Kidney Journal","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Gitelman syndrome; Tubulopathy; Medicine; Distal convoluted tubule; Endocrinology; Internal medicine; Excretion; Failure to thrive; Polyuria; Phenotype; Prostaglandin; Bartter syndrome; Hypocalciuria; Urinary system; Gene; Hypokalemia; Kidney; Reabsorption; Genetics; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001660149,0.0001037042,0.0002137008,0.00006777626,0.00006861996,0.00002000537,0.00008467276,0.0001470778,0.00003117491],"category_scores_gemma":[0.000766337,0.00007894301,0.00007763589,0.00009617101,0.0000859672,0.000007228979,0.00002203619,0.0001558136,0.000002992889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006722998,"about_ca_system_score_gemma":0.0001401598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003633596,"about_ca_topic_score_gemma":0.000003221649,"domain_scores_codex":[0.9988707,0.00025755,0.000377187,0.000196826,0.0001499488,0.0001477671],"domain_scores_gemma":[0.9990862,0.00005492362,0.0001654036,0.000154653,0.0001354513,0.0004033514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03611482,0.0004651222,0.3631381,0.0001390774,0.0003270257,0.00004642405,0.0002554011,0.0001367901,0.5899032,0.0001175758,0.003576301,0.005780212],"study_design_scores_gemma":[0.01492055,0.018982,0.8283206,0.000525842,0.0001932188,0.001388028,0.0001998536,0.0002156193,0.05865597,0.0009481937,0.07479814,0.0008519777],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922976,0.00003753658,0.006895439,0.0004469864,0.00007972397,0.0001338796,0.00001409725,0.000004798896,0.0000899457],"genre_scores_gemma":[0.9974492,0.00003241021,0.001535619,0.0004140412,0.0001548254,0.000003270746,0.00005084176,0.00001442614,0.0003453668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5312472,"threshold_uncertainty_score":0.3219203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01145488551085099,"score_gpt":0.270500604215877,"score_spread":0.259045718705026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}