{"id":"W2136559746","doi":"10.1093/ckj/sfu029","title":"A severe phenotype of Gitelman syndrome with increased prostaglandin excretion and favorable response to indomethacin","year":2014,"lang":"en","type":"article","venue":"Clinical Kidney Journal","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Gitelman syndrome; Tubulopathy; Medicine; Distal convoluted tubule; Endocrinology; Internal medicine; Excretion; Failure to thrive; Polyuria; Phenotype; Prostaglandin; Bartter syndrome; Hypocalciuria; Urinary system; Gene; Hypokalemia; Kidney; Reabsorption; Genetics; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138749,0.0009810798,0.0005479864,0.0006499079,0.0003060216,0.0002866212,0.0002271713,0.0009827039,0.001455856],"category_scores_gemma":[0.001437486,0.0002382083,0.0002710476,0.0003807465,0.0006374855,0.000288738,0.000349327,0.0007030462,0.0002164407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002775897,"about_ca_system_score_gemma":0.0003506744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007600406,"about_ca_topic_score_gemma":0.0008200497,"domain_scores_codex":[0.9998209,0.00003282414,0.00001966546,0.00004032193,0.0000444274,0.00004182589],"domain_scores_gemma":[0.9995385,0.0001530679,0.0001190377,0.00002475711,0.00002094976,0.0001436973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0002082924,0.00002256468,0.02060014,0.00006544262,0.00002546095,0.9486091,0.0001397409,0.0002037985,0.02506904,0.0004645895,0.0003685642,0.004223366],"study_design_scores_gemma":[0.00004895024,0.0002112815,0.04674723,0.00001499652,0.00002228901,0.9482723,0.00006202076,0.0002444515,0.00324655,0.0002645733,0.0008509166,0.00001450263],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881854,0.001338299,0.001635361,0.0008860895,0.00006634184,0.00005628947,0.0002605309,0.0002225606,0.007349093],"genre_scores_gemma":[0.9981919,0.0003709416,0.0006091704,0.000239171,0.00006945399,0.0000123775,0.00005085381,0.00001352292,0.0004425275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455856,"threshold_uncertainty_score":0.004870296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01145488551085099,"score_gpt":0.270500604215877,"score_spread":0.259045718705026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}