{"id":"W2136592357","doi":"10.1164/rccm.200405-612oc","title":"Progressive Transforming Growth Factor β1–induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor","year":2004,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":252,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Idiopathic pulmonary fibrosis; Fibrosis; Pulmonary fibrosis; Transforming growth factor; Extracellular matrix; Cancer research; Kinase; Lung; Pharmacology; Internal medicine; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001726864,0.0003476266,0.000886302,0.0002150742,0.0001978437,0.00003003837,0.0001525252,0.0001179729,0.0001380549],"category_scores_gemma":[0.0003733004,0.000253802,0.0002255149,0.0003056396,0.001125405,0.0004314999,0.00002545537,0.0006143178,0.000001286352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002205197,"about_ca_system_score_gemma":0.0003989589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008227547,"about_ca_topic_score_gemma":0.000001857402,"domain_scores_codex":[0.9976232,0.0001418053,0.0006848009,0.0003696014,0.0007344925,0.000446075],"domain_scores_gemma":[0.9972706,0.0001269994,0.0002429201,0.0001952886,0.001008644,0.001155579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.04155635,0.001877916,0.007306072,0.002643609,0.00073289,0.008409427,0.03629072,0.000001169881,0.6408901,0.0008515454,0.001496908,0.2579433],"study_design_scores_gemma":[0.0238032,0.4792316,0.01196496,0.01485445,0.005117373,0.00345195,0.1392333,0.00003335427,0.3137765,0.0006404825,0.005765454,0.002127448],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884935,0.006062348,0.0002704425,0.004343256,0.0002247452,0.0002916709,0.0001337081,0.00002808678,0.0001522261],"genre_scores_gemma":[0.9945388,0.00006448689,0.0002620242,0.00400045,0.00106306,0.00001153111,0.00001366372,0.00004200176,0.000003939007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4773536,"threshold_uncertainty_score":0.9999914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289258712286908,"score_gpt":0.3083990974195261,"score_spread":0.2955065102966571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}