{"id":"W2136604889","doi":"10.1089/ars.2006.8.529","title":"Hepatic Oxidative Stress During Aging: Effects of 8% Long-Term Calorie Restriction and Lifelong Exercise","year":2006,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute on Aging; American Heart Association","keywords":"Calorie restriction; Oxidative stress; Peroxynitrite; Internal medicine; Endocrinology; Nitric oxide; Reactive oxygen species; Chemistry; Glutathione; Downregulation and upregulation; Calorie; Senescence; Oxidative phosphorylation; Antioxidant; Metabolism; Biochemistry; Biology; Medicine; Superoxide; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001976356,0.0004839881,0.0003727963,0.0001819468,0.0001118129,0.0001651783,0.0001322588,0.0003207279,0.0004924287],"category_scores_gemma":[0.0001088493,0.0001377973,0.000296561,0.0001145783,0.0002306388,0.0002414097,0.0002273997,0.000314109,0.00008388006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001498963,"about_ca_system_score_gemma":0.000125513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006171253,"about_ca_topic_score_gemma":0.001018398,"domain_scores_codex":[0.9999331,0.00001071691,0.000007891656,0.00001581709,0.0000110039,0.00002154764],"domain_scores_gemma":[0.9998288,0.00001009898,0.00005797699,0.00002441033,0.00001977505,0.0000589517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009263437,0.0004051744,0.006532947,0.0001326181,0.00006727395,0.0001650877,0.00005937805,0.00007828655,0.9744369,0.00003623475,0.00004114139,0.008781544],"study_design_scores_gemma":[0.0003287856,0.03138193,0.2974068,0.00005220512,0.0004989319,0.0009480088,0.0003080001,0.0008396186,0.6657922,0.000196428,0.002207308,0.00003980513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982653,0.001173346,0.0003250939,0.0000270981,0.00001500297,0.00001029024,0.00004583118,0.00001104357,0.0001269313],"genre_scores_gemma":[0.9971063,0.0009087255,0.0005908368,0.0000546158,0.00002041424,0.00003662639,0.0002096811,0.000005211926,0.001067462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006171253,"threshold_uncertainty_score":0.001647294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006385438609587138,"score_gpt":0.2423844945085213,"score_spread":0.2359990558989342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}