{"id":"W2136608125","doi":"10.1038/sj.emboj.7601445","title":"Huntingtin inhibits caspase‐3 activation","year":2006,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; Hereditary Disease Foundation","keywords":"Huntingtin; Biology; Huntingtin Protein; Cell biology; Programmed cell death; Caspase; Caspase 3; Molecular biology; Mutant; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001905877,0.000102166,0.00007399041,0.00005626173,0.0004942684,0.0001659936,0.0002387794,0.00001561243,0.0001506668],"category_scores_gemma":[0.0004028933,0.00006742497,0.00006087647,0.0001941721,0.00007680778,0.0001344175,0.00004594421,0.0002302791,0.00009798008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002432837,"about_ca_system_score_gemma":0.00005364811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000011455,"about_ca_topic_score_gemma":0.000003586879,"domain_scores_codex":[0.9988257,0.0002596003,0.0001966924,0.0001590457,0.0003303259,0.0002285912],"domain_scores_gemma":[0.9994139,0.0001591498,0.000158494,0.0001594084,0.00005357046,0.00005545929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001240682,0.00004597796,0.0004141144,0.000001316279,0.000001003361,0.0000112901,0.00005316588,0.001169148,0.9916916,0.001060108,0.004839154,0.0007006374],"study_design_scores_gemma":[0.0002128748,0.00002633363,0.009303837,0.000009596682,0.000007262672,0.0001988419,0.00002833337,0.0001535023,0.9855843,0.003180795,0.001214327,0.00008003389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922221,0.00002079395,0.0004960654,0.001815551,0.0002426539,0.00009163954,0.00000291985,0.00002831478,0.005079921],"genre_scores_gemma":[0.9971515,0.000006392844,0.00006662634,0.001150446,0.0006657951,0.00000366735,5.577167e-7,0.00001543359,0.0009395605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008889723,"threshold_uncertainty_score":0.3801563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02609272675711102,"score_gpt":0.2552345728203908,"score_spread":0.2291418460632798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}