{"id":"W2136608125","doi":"10.1038/sj.emboj.7601445","title":"Huntingtin inhibits caspase‐3 activation","year":2006,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; Hereditary Disease Foundation","keywords":"Huntingtin; Biology; Huntingtin Protein; Cell biology; Programmed cell death; Caspase; Caspase 3; Molecular biology; Mutant; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003484474,0.0005607928,0.0005388111,0.0004738963,0.0003196586,0.0006980245,0.0004691764,0.0005765884,0.003269913],"category_scores_gemma":[0.0003902667,0.0002679788,0.0004711362,0.0002357729,0.0003491256,0.0004218786,0.0004070986,0.001256853,0.0009606676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006710607,"about_ca_system_score_gemma":0.0005625937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007338879,"about_ca_topic_score_gemma":0.001371085,"domain_scores_codex":[0.9997254,0.00005131863,0.0000330612,0.00003511823,0.00005838217,0.00009671371],"domain_scores_gemma":[0.9997894,0.00006571,0.00002828001,0.00003542862,0.00002316768,0.00005810413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002051533,0.0004376533,0.0004012712,0.0002131275,0.000089249,0.0003214673,0.00006581889,0.0001945867,0.9868777,0.0005885948,0.001037758,0.007721221],"study_design_scores_gemma":[0.0003669194,0.0009251799,0.00370106,0.00002096613,0.00003294833,0.0007462589,0.0000369886,0.0009666539,0.9887344,0.0003820013,0.004075125,0.00001155711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856508,0.004457468,0.002131844,0.0004169793,0.0002455216,0.00008263932,0.0005320666,0.0002180662,0.00626454],"genre_scores_gemma":[0.9920031,0.001699584,0.001255819,0.0001701412,0.00004314926,0.00005950448,0.001091287,0.00003138329,0.00364602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003269913,"threshold_uncertainty_score":0.01093894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02609272675711102,"score_gpt":0.2552345728203908,"score_spread":0.2291418460632798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}