{"id":"W2136614883","doi":"10.2217/nnm.12.69","title":"Challenges in Neuroprotective Nanomedicine Development: Progress Towards Noninvasive Gene Therapy of Glaucoma","year":2012,"lang":"en","type":"review","venue":"Nanomedicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Glaucoma; Gene delivery; Genetic enhancement; Medicine; Nanomedicine; Optic nerve; Retina; Neuroscience; Ophthalmology; Nanotechnology; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000632938,0.0006304686,0.001605834,0.0003814567,0.00004343292,0.000005105196,0.0004748493,0.0005059654,0.0000400799],"category_scores_gemma":[0.00006425384,0.0004590306,0.0002045266,0.0003990251,0.0003453558,0.000005987759,0.0001831476,0.0003021257,0.00001384193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007160337,"about_ca_system_score_gemma":0.0007952076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001107162,"about_ca_topic_score_gemma":0.00002068442,"domain_scores_codex":[0.9972267,0.0001811233,0.0009449994,0.0006904897,0.0004033813,0.0005533759],"domain_scores_gemma":[0.9986299,0.00003017979,0.0005516433,0.0004813794,0.0001460867,0.0001607536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007758884,0.0001757651,0.000270977,0.003202734,0.0002220896,0.00002558828,0.0003407848,1.933019e-8,0.0001927551,0.000008426665,0.00003357054,0.9954497],"study_design_scores_gemma":[0.001285356,0.0006212811,0.003431865,0.003560949,0.00008690042,0.00009024117,0.0001119564,1.069867e-7,0.002258741,0.000006668707,0.9880726,0.0004733143],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002681553,0.9936481,0.00003697949,0.00009902562,0.0003291651,0.001346147,0.000008280261,0.00001429051,0.001836533],"genre_scores_gemma":[0.005344868,0.9926942,0.0004137518,0.00004953683,0.0003582126,0.000389004,0.000472615,0.00008730485,0.0001905082],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9949764,"threshold_uncertainty_score":0.9997861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08230208760841133,"score_gpt":0.3228704536131444,"score_spread":0.2405683660047331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}