{"id":"W2136614883","doi":"10.2217/nnm.12.69","title":"Challenges in Neuroprotective Nanomedicine Development: Progress Towards Noninvasive Gene Therapy of Glaucoma","year":2012,"lang":"en","type":"review","venue":"Nanomedicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Glaucoma; Gene delivery; Genetic enhancement; Medicine; Nanomedicine; Optic nerve; Retina; Neuroscience; Ophthalmology; Nanotechnology; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001180447,0.000844999,0.001352682,0.001825597,0.0004041418,0.001180333,0.0009198074,0.001951682,0.002142519],"category_scores_gemma":[0.0008404956,0.0004207469,0.0004734421,0.001611214,0.000878964,0.002422482,0.0007654181,0.002385391,0.001651327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008993123,"about_ca_system_score_gemma":0.001206081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009329648,"about_ca_topic_score_gemma":0.001432775,"domain_scores_codex":[0.9996887,0.00006237352,0.00003610036,0.00005099121,0.0001316331,0.00003010275],"domain_scores_gemma":[0.9995503,0.000243978,0.00004470081,0.00001464281,0.0001163941,0.00002997589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006454083,0.0001264175,0.0001618912,0.01610449,0.00005471651,0.0004957485,0.000185822,0.0008157524,0.01159511,0.01336147,0.02286347,0.9341707],"study_design_scores_gemma":[0.00001491586,0.0001287911,0.0003889202,0.001782034,0.00004134694,0.001733463,0.0001060445,0.0002342453,0.003004694,0.004041588,0.9884982,0.00002587702],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001814162,0.9978907,0.0004507373,0.0004133126,0.0001685008,0.000004625102,0.000005790339,0.000007934807,0.0008770627],"genre_scores_gemma":[0.001129087,0.9968107,0.0007597178,0.0002830823,0.0001673371,0.0000112584,0.00001198984,0.000003002452,0.0008236351],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002142519,"threshold_uncertainty_score":0.007167459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08230208760841133,"score_gpt":0.3228704536131444,"score_spread":0.2405683660047331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}