{"id":"W2136629665","doi":"10.1093/hmg/ddn344","title":"Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Biology; Gonadotropin-releasing hormone; Endocrinology; Internal medicine; Homeobox; Psychological repression; Repressor; Gene; Enhancer; Transcription factor; Gene expression; Cell biology; Hormone; Genetics; Luteinizing hormone; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007790048,0.0004984575,0.0003605666,0.0001451458,0.0006980725,0.00007533435,0.0004820699,0.0002447893,0.0000261784],"category_scores_gemma":[0.00003911605,0.0005621929,0.0001890659,0.0001928848,0.0001969015,0.000006694859,0.0004847499,0.0002074413,0.00003626219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005298819,"about_ca_system_score_gemma":0.0001889786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000280382,"about_ca_topic_score_gemma":0.000010107,"domain_scores_codex":[0.9971374,0.00009843896,0.0006136203,0.0008910726,0.0004037977,0.0008556686],"domain_scores_gemma":[0.9984565,0.000005542807,0.00021233,0.0008905985,0.0001395838,0.0002953952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000002979266,0.00009147455,0.007110377,0.00003047547,0.0001378636,0.0001057729,0.0001509144,0.0008489804,0.9909507,0.00001314032,0.0001466248,0.0004107007],"study_design_scores_gemma":[0.000896205,0.0003317155,0.7074134,0.00002652347,0.00003978365,0.00216031,0.00002674212,0.00005756126,0.2824736,0.00002594861,0.005904865,0.0006433438],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926935,0.004760795,0.001675719,0.00004975735,0.0001352809,0.0003904061,0.000008171985,0.0000565348,0.0002298735],"genre_scores_gemma":[0.9874554,0.0008934848,0.01029878,0.0001648266,0.0001175785,0.00004075235,0.0001513256,0.0001429194,0.0007349568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7084771,"threshold_uncertainty_score":0.999683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126599211660688,"score_gpt":0.2227246949130071,"score_spread":0.2100647737469383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}