{"id":"W2136677555","doi":"10.1101/cshperspect.a019752","title":"Mechanisms of Antifungal Drug Resistance","year":2014,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Medicine","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":622,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Antifungal; Antifungal drug; Drug resistance; Drug; Efflux; Antifungal drugs; Fluconazole; Biology; Multiple drug resistance; Resistance (ecology); Intensive care medicine; Pharmacology; Medicine; Microbiology; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007142196,0.001073497,0.001656787,0.003142621,0.0004258085,0.002168892,0.001347263,0.0016482,0.005041755],"category_scores_gemma":[0.001045794,0.0003009326,0.0008374287,0.001801803,0.001074869,0.001772167,0.001167397,0.002124383,0.00329976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001060035,"about_ca_system_score_gemma":0.001283371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000789515,"about_ca_topic_score_gemma":0.0009207921,"domain_scores_codex":[0.9993414,0.0001108,0.00007494663,0.00009719963,0.0003012251,0.00007433177],"domain_scores_gemma":[0.9995011,0.0001760272,0.00009343022,0.00002517414,0.0001539332,0.00005032209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006207132,0.00007548198,0.0006804246,0.01177764,0.0001215348,0.0008528854,0.0001558102,0.0004143784,0.005131257,0.01243967,0.03879886,0.9294899],"study_design_scores_gemma":[0.00001359832,0.000061768,0.000864168,0.00244615,0.00007401217,0.00438038,0.00007127959,0.0001172341,0.001541279,0.003827065,0.9865794,0.00002370445],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002048849,0.995708,0.0002813865,0.0005158444,0.0002012035,0.000009446804,0.00002932894,0.00001567887,0.00303417],"genre_scores_gemma":[0.002853377,0.9942189,0.0003373762,0.0004366339,0.0002727694,0.00001409657,0.00006548587,0.000004180483,0.001797176],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005041755,"threshold_uncertainty_score":0.01686633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03660985135455397,"score_gpt":0.3465387099850441,"score_spread":0.3099288586304901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}