{"id":"W2136712438","doi":"10.1016/j.virol.2004.06.028","title":"In vivo mutational analysis of the N-terminal region of HIV-1 Nef reveals critical motifs for the development of an AIDS-like disease in CD4C/HIV transgenic mice","year":2004,"lang":"en","type":"article","venue":"Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Myristoylation; Mutant; Transgene; CD8; In vivo; Genetically modified mouse; Mutation; Molecular biology; Phenotype; Allele; In vitro; Virology; Immunology; Cell biology; Immune system; Genetics; Gene; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371448,0.0004694712,0.0001703897,0.0003867357,0.0002958987,0.0002805203,0.0003084998,0.0005812115,0.001802641],"category_scores_gemma":[0.0001479825,0.0002364593,0.0002218003,0.0001081665,0.0004455814,0.000205439,0.000138087,0.001032107,0.000424686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003589072,"about_ca_system_score_gemma":0.000189079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008063149,"about_ca_topic_score_gemma":0.001151459,"domain_scores_codex":[0.9998971,0.00001603245,0.000008285188,0.00002270539,0.00002218536,0.00003358953],"domain_scores_gemma":[0.9997486,0.00006646436,0.00008313878,0.00002231076,0.00001330254,0.00006606976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001069853,0.00002792957,0.00006173908,0.000007161048,0.000001946695,0.00005183465,0.000007109225,0.00005843471,0.9992366,0.000141411,0.00001561666,0.0002833208],"study_design_scores_gemma":[0.00005068887,0.0001874597,0.002886611,0.000009032956,0.00001789658,0.0006248818,0.00002458911,0.001312127,0.9934657,0.0001698082,0.001245085,0.000006127709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959062,0.0003032307,0.002301305,0.00009915552,0.00001646204,0.00002002694,0.0002494229,0.0000646639,0.001039374],"genre_scores_gemma":[0.9951239,0.000201368,0.002110312,0.00004459875,0.000009427209,0.00001765695,0.0002789678,0.00005086808,0.002162925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001802641,"threshold_uncertainty_score":0.0060305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01918812695722502,"score_gpt":0.2982065653528097,"score_spread":0.2790184383955847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}