{"id":"W2136731336","doi":"10.2217/rme.10.21","title":"Spontaneous Reversal of the Developmental Aging of Normal Human Cells Following Transcriptional Reprogramming","year":2010,"lang":"en","type":"article","venue":"Regenerative Medicine","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Telomere; Reprogramming; Biology; Induced pluripotent stem cell; Telomerase; KLF4; Embryonic stem cell; SOX2; Transcriptome; Somatic cell; Cell culture; Stem cell; Cell biology; Genetics; Cell; Molecular biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003811898,0.0002152306,0.0002002178,0.0002064865,0.00007694971,0.0002661057,0.0002289217,0.0002346581,0.001194789],"category_scores_gemma":[0.000406225,0.00009570661,0.0002587067,0.0001127889,0.0001751834,0.0001673017,0.0002656312,0.0003501345,0.0004713808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001109891,"about_ca_system_score_gemma":0.0001190415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009276884,"about_ca_topic_score_gemma":0.0001115935,"domain_scores_codex":[0.9998185,0.00002324041,0.00003116665,0.00005703729,0.00004774137,0.0000223581],"domain_scores_gemma":[0.9996122,0.00007183488,0.0001280319,0.00009594096,0.00005709027,0.0000350579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005528178,0.00002153758,0.00141934,0.00005012706,0.000007434696,0.0001507157,0.00002403674,0.00005821255,0.9930861,0.0001162816,0.00003403065,0.004976867],"study_design_scores_gemma":[0.000006804807,0.0004481277,0.02005757,0.00001133331,0.00003330876,0.001680727,0.00003355259,0.0006116313,0.9738281,0.00008325168,0.003200058,0.000005371256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778513,0.001922756,0.01741395,0.00005407349,0.00005022053,0.00007132986,0.000617673,0.00024786,0.001770774],"genre_scores_gemma":[0.9917956,0.0009368194,0.004233386,0.00006823501,0.00001792602,0.00006049324,0.001158552,0.00004749211,0.001681536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001194789,"threshold_uncertainty_score":0.003996909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0188823932638026,"score_gpt":0.272567590989187,"score_spread":0.2536851977253844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}