{"id":"W2136738141","doi":"10.4049/jimmunol.1102609","title":"Antigen-Independent Induction of Tim-3 Expression on Human T Cells by the Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Is Associated with Proliferation and Is Dependent on the Phosphoinositide 3-Kinase Pathway","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Maple Leaf Medical Clinic; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Innovation Trust","keywords":"Cytotoxic T cell; CD28; Biology; IL-2 receptor; Interleukin 21; T cell; Cytokine; Immunology; CD8; Antigen-presenting cell; ZAP70; Antigen; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001361936,0.0002713728,0.0004477142,0.0001015574,0.000635187,0.00002025014,0.0003145713,0.0003651019,0.000125173],"category_scores_gemma":[0.00005223926,0.0001273844,0.00007303831,0.0001064006,0.000548705,0.000107901,0.000112943,0.00093942,0.00001000572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007586341,"about_ca_system_score_gemma":0.00004989951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001468813,"about_ca_topic_score_gemma":0.00006030943,"domain_scores_codex":[0.9975195,0.001263319,0.000521305,0.0001892005,0.0001181729,0.0003884955],"domain_scores_gemma":[0.9980813,0.0004292877,0.0009503021,0.0003455916,0.0001655644,0.00002792573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001351931,0.000296095,0.003581357,0.000004914874,0.0004230185,0.00000255419,0.003198682,0.000004813121,0.9858269,0.000183707,0.002800775,0.002325259],"study_design_scores_gemma":[0.001659104,0.002796403,0.03132608,0.0001107205,0.00009198343,0.0005029875,0.001605242,0.000001590328,0.9587923,0.0001661883,0.002795805,0.000151644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991899,0.005126694,0.00002300977,0.001851168,0.0005160925,0.0003639723,0.0001090332,0.00001061172,0.0001004474],"genre_scores_gemma":[0.9972224,0.001605277,0.000003727879,0.0007360666,0.00006752206,0.00001208692,0.00001891448,0.0000207498,0.0003132207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02774473,"threshold_uncertainty_score":0.5194587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492820765678722,"score_gpt":0.2337186937012707,"score_spread":0.2187904860444835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}