{"id":"W2136738141","doi":"10.4049/jimmunol.1102609","title":"Antigen-Independent Induction of Tim-3 Expression on Human T Cells by the Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Is Associated with Proliferation and Is Dependent on the Phosphoinositide 3-Kinase Pathway","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Maple Leaf Medical Clinic; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Innovation Trust","keywords":"Cytotoxic T cell; CD28; Biology; IL-2 receptor; Interleukin 21; T cell; Cytokine; Immunology; CD8; Antigen-presenting cell; ZAP70; Antigen; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001078544,0.000407288,0.0001790302,0.0001522387,0.0001451494,0.0003551389,0.00009904301,0.0001993477,0.002177743],"category_scores_gemma":[0.0001142878,0.00009088478,0.0003320812,0.0001650478,0.000159291,0.0002030135,0.0002744481,0.0004843834,0.0006870145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508766,"about_ca_system_score_gemma":0.000178391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000196529,"about_ca_topic_score_gemma":0.0002354595,"domain_scores_codex":[0.9998717,0.00001974945,0.000009310016,0.00002442121,0.00002552965,0.0000493139],"domain_scores_gemma":[0.9999461,0.000008993112,0.00001274687,0.00001061084,0.00001088676,0.0000106417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002336563,0.00002314896,0.0002278367,0.00005236079,0.000004118545,0.00005729391,0.00002999443,0.00003483483,0.9978344,0.0000625847,0.00004605105,0.00139367],"study_design_scores_gemma":[0.00003092618,0.000543474,0.006219401,0.00001215065,0.00002382906,0.0003634573,0.00004857763,0.0003447309,0.9892671,0.00007148618,0.003070258,0.000004653196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924561,0.001371228,0.003126686,0.00005597123,0.00003729483,0.00009368627,0.0006267623,0.00005630364,0.002175971],"genre_scores_gemma":[0.9940462,0.001138941,0.001675887,0.00007580868,0.00002509306,0.00009628919,0.001120414,0.000009453001,0.001811907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002177743,"threshold_uncertainty_score":0.007285297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492820765678722,"score_gpt":0.2337186937012707,"score_spread":0.2187904860444835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}