{"id":"W2136791626","doi":"10.1002/chir.20669","title":"Nonlinear stereoselective pharmacokinetics of ketoconazole in rat after administration of racemate","year":2008,"lang":"en","type":"article","venue":"Chirality","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Stereoselectivity; Chemistry; Enantiomer; Pharmacokinetics; Ketoconazole; Oral administration; Volume of distribution; Pharmacology; Stereoisomerism; Blood plasma; Stereochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005920187,0.000212717,0.0004542557,0.0001339168,0.00005238008,0.000003070798,0.0002126661,0.0001888369,0.0006236202],"category_scores_gemma":[0.00005127861,0.0002113828,0.000126068,0.0003245265,0.0003284848,0.00009402786,0.00007768305,0.0004466432,0.00001638681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002773619,"about_ca_system_score_gemma":0.0001732946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001906285,"about_ca_topic_score_gemma":0.00001670244,"domain_scores_codex":[0.9980642,0.0004142857,0.00073625,0.0002736783,0.0001940178,0.0003175682],"domain_scores_gemma":[0.9990424,0.000131182,0.0003023517,0.0002037847,0.0001801439,0.0001401629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006332356,0.003423533,0.2235729,0.0004573264,0.0002599143,0.0001788412,0.003856677,0.0006615251,0.7516116,0.0003116545,0.0006488452,0.008684836],"study_design_scores_gemma":[0.002959609,0.0001320229,0.06693859,0.00001451882,0.00009400502,0.000021483,0.00003095524,0.001879739,0.9149526,0.0002516974,0.01251986,0.0002048615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952119,0.000959169,0.00004723365,0.000129432,0.0005851313,0.0005620967,0.0001995367,0.00001935365,0.002286145],"genre_scores_gemma":[0.9980109,0.0006733565,0.0004588915,0.0004035906,0.0001389625,0.00006244012,0.00002560245,0.00001792219,0.0002083348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1633411,"threshold_uncertainty_score":0.861994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1073872113068054,"score_gpt":0.4315809384688826,"score_spread":0.3241937271620772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}