{"id":"W2136795157","doi":"10.1091/mbc.e08-12-1252","title":"The First Propeller Domain of LRP6 Regulates Sensitivity to DKK1","year":2009,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"LRP6; DKK1; Wnt signaling pathway; Biology; Cell biology; Internalization; LRP5; Mutant; Signal transduction; Biochemistry; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023054,0.0001820325,0.0001981356,0.0001855834,0.0001459568,0.0003395528,0.0001403041,0.0002090054,0.001085507],"category_scores_gemma":[0.0001663429,0.0001458655,0.0001750887,0.0000922526,0.0002113349,0.0001456073,0.0001424971,0.0004597647,0.000397784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005034939,"about_ca_system_score_gemma":0.0001764781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007550187,"about_ca_topic_score_gemma":0.0007187493,"domain_scores_codex":[0.99986,0.00002091348,0.00001118315,0.00002568386,0.0000328032,0.00004939414],"domain_scores_gemma":[0.9998579,0.00002487632,0.00004699441,0.00001105372,0.00001665394,0.00004247369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006640903,0.000007424614,0.000204484,0.000007297004,0.000001097147,0.00002984747,0.000005944156,0.00002456462,0.9993538,0.00002567634,0.00001261409,0.0002609732],"study_design_scores_gemma":[0.00001211397,0.00008031218,0.0188065,0.000002031628,0.000007333958,0.0002765942,0.00002574281,0.0008410851,0.9789362,0.00002585281,0.0009804487,0.000005738883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998393,0.0004685618,0.0004962078,0.00004089752,0.000006820974,0.000003886214,0.0001227001,0.00002151691,0.0004464452],"genre_scores_gemma":[0.9987401,0.0001904639,0.0003313622,0.00001936615,0.000002494,0.000004360599,0.0001694797,0.000008196608,0.0005340738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001085507,"threshold_uncertainty_score":0.003653109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003774974675432606,"score_gpt":0.2129718725129505,"score_spread":0.2091968978375179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}