{"id":"W2136812855","doi":"10.1038/npp.2012.191","title":"Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors’ and Longitudinal ‘Targets’","year":2012,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":433,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Medical Research Council; Regione Lombardia; Ministero della Salute; Servier; European Commission; National Institute for Health and Care Research; King's College London; Eli Lilly and Company; Psychiatry Research Trust; South London and Maudsley NHS Foundation Trust; National Alliance for Research on Schizophrenia and Depression","keywords":"Escitalopram; Antidepressant; Internal medicine; Nortriptyline; Proinflammatory cytokine; FKBP5; Medicine; Neurotrophic factors; Glucocorticoid receptor; Endocrinology; Citalopram; Major depressive disorder; Oncology; Brain-derived neurotrophic factor; Tumor necrosis factor alpha; Glucocorticoid; Psychology; Receptor; Inflammation; Amygdala; Amitriptyline","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002088821,0.0001539226,0.0002744424,0.0001648267,0.0001018932,0.0002516219,0.0001005005,0.000265002,0.0004994991],"category_scores_gemma":[0.0002917178,0.0001006511,0.0002617492,0.0002755908,0.00012006,0.00006189548,0.0001173067,0.0002036071,0.00009657387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001030661,"about_ca_system_score_gemma":0.00010595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001248189,"about_ca_topic_score_gemma":0.002363574,"domain_scores_codex":[0.999882,0.00003772019,0.000007345999,0.00004179998,0.00001298323,0.0000180563],"domain_scores_gemma":[0.9998385,0.0000427203,0.00006109104,0.00001551703,0.00001457848,0.00002758909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002797589,0.00005137651,0.9800852,0.00003534236,0.0001919261,0.0002347768,0.0001028198,0.00009677461,0.01265294,0.00002131859,0.0001506339,0.003579258],"study_design_scores_gemma":[0.00001417032,0.000132616,0.9992223,0.000001732343,0.00004331576,0.00012288,0.00003731278,0.00006852002,0.0002433459,0.0000097805,0.0001027548,0.00000125427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991599,0.0003252577,0.00007706077,0.00002672135,0.00000378959,0.000002807204,0.0003005473,0.000001454755,0.0001023815],"genre_scores_gemma":[0.9990929,0.0001265753,0.0001423031,0.00004064652,0.000006298937,0.000009384243,0.0003791047,0.000001673719,0.0002010581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248189,"threshold_uncertainty_score":0.002481818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04129203917185755,"score_gpt":0.3167356951785351,"score_spread":0.2754436560066776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}