{"id":"W2136812855","doi":"10.1038/npp.2012.191","title":"Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors’ and Longitudinal ‘Targets’","year":2012,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":433,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Medical Research Council; Regione Lombardia; Ministero della Salute; Servier; European Commission; National Institute for Health and Care Research; King's College London; Eli Lilly and Company; Psychiatry Research Trust; South London and Maudsley NHS Foundation Trust; National Alliance for Research on Schizophrenia and Depression","keywords":"Escitalopram; Antidepressant; Internal medicine; Nortriptyline; Proinflammatory cytokine; FKBP5; Medicine; Neurotrophic factors; Glucocorticoid receptor; Endocrinology; Citalopram; Major depressive disorder; Oncology; Brain-derived neurotrophic factor; Tumor necrosis factor alpha; Glucocorticoid; Psychology; Receptor; Inflammation; Amygdala; Amitriptyline","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009675981,0.0002802201,0.0002993424,0.0001805262,0.0003006442,0.00004875367,0.000381185,0.00008171276,0.0001258623],"category_scores_gemma":[0.0004997722,0.0001850038,0.00003425419,0.0004681299,0.0001751284,0.0002567484,0.0001106249,0.0004633408,0.00001034594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002017735,"about_ca_system_score_gemma":0.00002409379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009880555,"about_ca_topic_score_gemma":0.00001298208,"domain_scores_codex":[0.99449,0.003543115,0.0003352951,0.0005869797,0.0003736325,0.000670958],"domain_scores_gemma":[0.9975427,0.001832056,0.0001910117,0.0002612429,0.00002569197,0.0001472816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001181274,0.000726935,0.6378239,0.000006442957,0.00001345825,0.00009477721,0.001921199,0.000004407395,0.3574014,9.279304e-7,0.0002916594,0.0005336676],"study_design_scores_gemma":[0.003556378,0.0005640395,0.9681906,0.00001391223,0.0000394138,0.00002419238,0.0002963424,0.0001283724,0.02680151,0.000004054409,0.0001834509,0.0001977462],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997929,0.0001782783,0.00003424365,0.0002256331,0.0004886989,0.0009068064,0.00005753436,0.00009027058,0.000089487],"genre_scores_gemma":[0.9987774,0.00005779317,0.00001614466,0.00077252,0.0001760822,0.0001082031,0.000008360273,0.00003872988,0.00004476856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3305999,"threshold_uncertainty_score":0.7544236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04129203917185755,"score_gpt":0.3167356951785351,"score_spread":0.2754436560066776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}