{"id":"W2136838641","doi":"10.1038/sj.mn.7800212","title":"Blood—Brain Barrier Permeability Precedes Senile Plaque Formation in an Alzheimer Disease Model","year":2003,"lang":"en","type":"article","venue":"Microcirculation","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":336,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Blood–brain barrier; Senile plaques; Disease; Pathology; Alzheimer's disease; Medicine; Permeability (electromagnetism); Chemistry; Internal medicine; Central nervous system; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004330612,0.0005221567,0.0006260767,0.0008814378,0.0002821338,0.000525766,0.0002791164,0.0005905795,0.002112543],"category_scores_gemma":[0.000351732,0.000344364,0.0003514832,0.0002613256,0.0003809502,0.000542194,0.0003834135,0.001210577,0.0005875895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004113255,"about_ca_system_score_gemma":0.0002683342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00095839,"about_ca_topic_score_gemma":0.001591208,"domain_scores_codex":[0.9997477,0.00002990055,0.00002528505,0.00005757845,0.00007481289,0.00006469744],"domain_scores_gemma":[0.999603,0.00003616022,0.0001648852,0.0000276846,0.00005800737,0.0001102234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006649481,0.000158406,0.001358834,0.00004699922,0.00001782299,0.000187951,0.00007928558,0.00002602431,0.9962887,0.00004690134,0.00004649048,0.001077637],"study_design_scores_gemma":[0.00006025581,0.003882854,0.0958453,0.00004945021,0.0001389961,0.001593025,0.0001706615,0.000768277,0.8952689,0.0002496493,0.001951407,0.00002119426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995589,0.00200094,0.001279056,0.00005925258,0.00003265498,0.00003308339,0.000183301,0.00005869198,0.0007640753],"genre_scores_gemma":[0.9935048,0.00135217,0.001602083,0.00005994682,0.00002065942,0.00007617013,0.0003959446,0.00001897119,0.002969353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002112543,"threshold_uncertainty_score":0.007067144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04642477081300929,"score_gpt":0.2784600048518194,"score_spread":0.2320352340388101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}