{"id":"W2136867954","doi":"10.1139/o10-150","title":"Mechanism of tumor resistance to cisplatin mediated by the copper transporter ATP7BThis paper is one of a selection of papers published in a Special Issue entitled CSBMCB 53rd Annual Meeting — Membrane Proteins in Health and Disease, and has undergone the Journal’s usual peer review process.","year":2011,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Trace Elements in Health","field":"Nursing","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Cisplatin; Efflux; ATP7A; Cytosol; In vivo; Chemistry; Transporter; Platinum; ATPase; Biochemistry; Biology; Pharmacology; Cell biology; Enzyme; Chemotherapy; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004796844,0.0005943103,0.0009245701,0.001470476,0.0002712927,0.0006258028,0.0007234111,0.0009323645,0.00274196],"category_scores_gemma":[0.0005041043,0.0002221739,0.0003002148,0.001649544,0.0002907559,0.001000242,0.0003729574,0.0007735975,0.001976801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006082092,"about_ca_system_score_gemma":0.0009155296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008769601,"about_ca_topic_score_gemma":0.001861267,"domain_scores_codex":[0.9998447,0.00002284971,0.00002416464,0.00002191375,0.0000713082,0.00001507581],"domain_scores_gemma":[0.9997665,0.00005559116,0.00004145554,0.000006213882,0.0001054697,0.00002466438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006784405,0.00004845008,0.0002138986,0.01103183,0.00006490985,0.00027,0.00004050253,0.0001712853,0.002997209,0.001514333,0.04470922,0.9388705],"study_design_scores_gemma":[0.00001624414,0.00009294125,0.000867327,0.0013305,0.00008555366,0.001472837,0.00004600864,0.0000672821,0.001402143,0.0007498162,0.9938542,0.00001516594],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002143328,0.9978026,0.0001220203,0.0004737356,0.0004225759,0.000005413037,0.00001362723,0.000007715107,0.0009379119],"genre_scores_gemma":[0.0009094611,0.9975198,0.0001729657,0.0002021435,0.0001932988,0.000006663948,0.00002389189,0.000001397751,0.0009703352],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00274196,"threshold_uncertainty_score":0.009172797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02340264891574236,"score_gpt":0.2917067840185387,"score_spread":0.2683041351027964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}