{"id":"W2136919958","doi":"10.1002/bit.22727","title":"Serum‐free scaled up expansion and differentiation of murine embryonic stem cells to osteoblasts in suspension bioreactors","year":2010,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research","keywords":"Embryonic stem cell; Fetal bovine serum; Cell biology; Stem cell; Osteocalcin; Bioreactor; Cell culture; Cellular differentiation; Chemistry; Regenerative medicine; Biomedical engineering; Biology; Cell; Medicine; Alkaline phosphatase; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005478285,0.0004889563,0.0004169748,0.0003442819,0.000178562,0.0003735719,0.0003991589,0.0002843926,0.0005557635],"category_scores_gemma":[0.0002543833,0.0001885569,0.0003025404,0.0002380401,0.000225106,0.0001987849,0.0003807735,0.0004840416,0.0005337241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002091272,"about_ca_system_score_gemma":0.0003161996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005889213,"about_ca_topic_score_gemma":0.001418471,"domain_scores_codex":[0.9996209,0.00004098325,0.00005151568,0.00005531397,0.000201682,0.00002969818],"domain_scores_gemma":[0.9998293,0.00004590316,0.0000302173,0.00002382874,0.00004315975,0.00002756866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001374846,0.00001520542,0.000068505,0.00002358498,0.000001461284,0.00001537927,0.00001056327,0.0001063597,0.9985994,0.0000455579,0.00003585654,0.001064614],"study_design_scores_gemma":[0.000009164046,0.000116201,0.0007060074,0.000005327915,0.00001295022,0.00005117089,0.0000108178,0.0009685441,0.9959863,0.00004615504,0.002082674,0.000004634547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8599888,0.003396948,0.1294946,0.0002185872,0.0001857329,0.0005245292,0.001335595,0.0006085762,0.004246489],"genre_scores_gemma":[0.8268058,0.004293607,0.1582022,0.0001291901,0.00005985685,0.000641178,0.002608984,0.0001673139,0.007091917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005889213,"threshold_uncertainty_score":0.002897203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006010789379343106,"score_gpt":0.2121351233296704,"score_spread":0.2061243339503273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}