{"id":"W2136919958","doi":"10.1002/bit.22727","title":"Serum‐free scaled up expansion and differentiation of murine embryonic stem cells to osteoblasts in suspension bioreactors","year":2010,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research","keywords":"Embryonic stem cell; Fetal bovine serum; Cell biology; Stem cell; Osteocalcin; Bioreactor; Cell culture; Cellular differentiation; Chemistry; Regenerative medicine; Biomedical engineering; Biology; Cell; Medicine; Alkaline phosphatase; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338029,0.0001452649,0.0001685848,0.0002147708,0.00002889674,0.000008717695,0.0001557794,0.0004475785,0.000003117899],"category_scores_gemma":[0.000023794,0.0001333814,0.00002386681,0.0001731611,0.0001043484,0.000005722979,0.0003823337,0.0002167832,0.000001287862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008288958,"about_ca_system_score_gemma":0.00001100194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001690067,"about_ca_topic_score_gemma":0.0001987626,"domain_scores_codex":[0.9991599,0.00001551206,0.0001724945,0.0003284533,0.00008383617,0.0002397515],"domain_scores_gemma":[0.9995227,0.0000123002,0.00003955422,0.0003271764,0.00002637467,0.00007189369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004894293,0.0000239428,0.004021899,0.0000585027,0.0000115385,0.00000276083,0.00001502326,0.00001454854,0.9904717,0.00003382325,0.00001246441,0.005284836],"study_design_scores_gemma":[0.0005860077,0.0002147049,0.02612775,0.00003763119,0.000005780473,0.00001519436,0.00003699689,0.000652575,0.9718935,0.000005554065,0.0002903993,0.0001338425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985926,0.0002427671,0.0003245141,0.0003817399,0.000185926,0.0002294716,0.00001226978,0.00002629115,0.000004427819],"genre_scores_gemma":[0.9992181,0.0003186836,0.0003393049,0.000007720497,0.00002491627,0.000007216021,0.000007945843,0.00001509674,0.00006101505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02210585,"threshold_uncertainty_score":0.5439138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006010789379343106,"score_gpt":0.2121351233296704,"score_spread":0.2061243339503273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}